InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CARD8

Summary

InnateDB Protein

IDBP-478256.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CARD8

Protein Name

caspase recruitment domain family, member 8

Synonyms

CARDINAL; DACAR; DAKAR; NDPP; NDPP1; TUCAN;

Species

Homo sapiens

Ensembl Protein

ENSP00000429839

InnateDB Gene

IDBG-60120 (CARD8)

Protein Structure

UniProt Annotation

Function

Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15030775}. Nucleus {ECO:0000269PubMed:15030775}.

Disease Associations

Tissue Specificity

High expression in lung, ovary, testis and placenta. Lower expression in heart, kidney and liver. Also expressed in spleen, lymph node and bone marrow.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	19 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0032089	NACHT domain binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0050718	positive regulation of interleukin-1 beta secretion