Version 5.4
Homo sapiens Protein: CEP120
Summary
InnateDB Protein IDBP-478285.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CEP120
Protein Name centrosomal protein 120kDa
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000422089
InnateDB Gene IDBG-39078 (CEP120)
Protein Structure
UniProt Annotation
Function Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. May play a role in centriole duplication during mitosis (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Regulates the localization of TACC3 to the centrosome in neural progenitors in vivo. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
Protein Structure and Domains
PDB ID
InterPro IPR000008 C2 domain
IPR022136 Domain of unknown function DUF3668
PFAM PF00168
PF12416
PRINTS PR00360
PIRSF
SMART SM00239
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N960
PhosphoSite PhosphoSite-Q8N960
TrEMBL F8VRV0
UniProt Splice Variant
Entrez Gene 153241
UniGene Hs.640322
RefSeq
HUGO HGNC:26690
OMIM 613446
CCDS
HPRD 08769
IMGT
EMBL AC010369 AC106792 AK093409 AK095646 AL833929 BC040527 BX648687 CR627324
GenPept BAC04155 BAC04596 CAD38785 CAH10371 CAH10561

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca