Version 5.4
Homo sapiens Gene: CEP120
Summary
InnateDB Gene IDBG-39078.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CEP120
Gene Name centrosomal protein 120kDa
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000168944
Encoded Proteins
IDBP-39080
centrosomal protein 120kDa
IDBP-39082
centrosomal protein 120kDa
IDBP-39084
centrosomal protein 120kDa
IDBP-474620
centrosomal protein 120kDa
IDBP-478202
centrosomal protein 120kDa
IDBP-478285
centrosomal protein 120kDa
IDBP-476228
centrosomal protein 120kDa
IDBP-482928
centrosomal protein 120kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that functions in the microtubule-dependent coupling of the nucleus and the centrosome. A similar protein in mouse plays a role in both interkinetic nuclear migration, which is a characteristic pattern of nuclear movement in neural progenitors, and in neural progenitor self-renewal. Mutations in this gene are predicted to result in neurogenic defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:123344885-123423592
Strand Reverse strand
Band q23.2
Transcripts
ENST00000306467 ENSP00000303058
ENST00000306481 ENSP00000307419
ENST00000328236 ENSP00000327504
ENST00000508138 ENSP00000422234
ENST00000510582 ENSP00000422382
ENST00000513565 ENSP00000422089
ENST00000508442 ENSP00000421620
ENST00000503049
ENST00000515110 ENSP00000428303
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0008283 cell proliferation
GO:0021987 cerebral cortex development
GO:0022008 neurogenesis
GO:0022027 interkinetic nuclear migration
GO:0030953 astral microtubule organization
GO:0032880 regulation of protein localization
GO:0032886 regulation of microtubule-based process
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000048799
View Gene Order
ENSBTAG00000013184
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.483209 Hs.597123 Hs.640322
RefSeq NM_001166226 NM_153223
HUGO
OMIM
CCDS CCDS4134 CCDS54890
HPRD 08769
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca