InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CNTF

Summary

InnateDB Protein

IDBP-47875.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CNTF

Protein Name

ciliary neurotrophic factor

Synonyms

HCNTF;

Species

Homo sapiens

Ensembl Protein

ENSP00000355370

InnateDB Gene

IDBG-409278 (CNTF)

Protein Structure

UniProt Annotation

Function

CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Nervous system.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005127	ciliary neurotrophic factor receptor binding
GO:0005138	interleukin-6 receptor binding
GO:0008083	growth factor activity

Biological Process

GO:0007165	signal transduction
GO:0008284	positive regulation of cell proliferation
GO:0040007	growth
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043524	negative regulation of neuron apoptotic process
GO:0046533	negative regulation of photoreceptor cell differentiation
GO:0046668	regulation of retinal cell programmed cell death
GO:0048644	muscle organ morphogenesis
GO:0048666	neuron development
GO:0070120	ciliary neurotrophic factor-mediated signaling pathway