|Homo sapiens Gene: CNTF|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||ciliary neurotrophic factor|
ciliary neurotrophic factor
|Useful resources||Stemformatics EHFPI ImmGen|
The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq, Oct 2010]
|Genomic Location||Chromosome 11:58622673-58625733|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
|UniProt Splice Variant|
|EMBL||AK314118 BC068030 BC074963 BC074964 CH471076 X55889 X55890 X60477 X60478 X60542|
|GenPept||AAH68030 AAH74963 AAH74964 BAG36809 CAA39374 CAA43009 CAA43032 EAW73819|
|RNA Seq Atlas||1270|