Version 5.4
Homo sapiens Gene: CNTF
Summary
InnateDB Gene IDBG-409278.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CNTF
Gene Name ciliary neurotrophic factor
Synonyms HCNTF
Species Homo sapiens
Ensembl Gene ENSG00000242689
Encoded Proteins
IDBP-47875
ciliary neurotrophic factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:58622673-58625733
Strand Forward strand
Band q12.1
Transcripts
ENST00000361987 ENSP00000355370
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005127 ciliary neurotrophic factor receptor binding
GO:0005138 interleukin-6 receptor binding
GO:0008083 growth factor activity
Biological Process
GO:0007165 signal transduction
GO:0008284 positive regulation of cell proliferation
GO:0040007 growth
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043524 negative regulation of neuron apoptotic process
GO:0046533 negative regulation of photoreceptor cell differentiation
GO:0046668 regulation of retinal cell programmed cell death
GO:0048644 muscle organ morphogenesis
GO:0048666 neuron development
GO:0070120 ciliary neurotrophic factor-mediated signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0097058 CRLF-CLCF1 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000079415
View Gene Order
ENSBTAG00000003624
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_000614
HUGO
OMIM
CCDS CCDS31554
HPRD 00347
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca