InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBR5

Summary

InnateDB Protein

IDBP-479178.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBR5

Protein Name

ubiquitin protein ligase E3 component n-recognin 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000429084

InnateDB Gene

IDBG-31165 (UBR5)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'- linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes. {ECO:0000250, ECO:0000269PubMed:21127351, ECO:0000269PubMed:21726808, ECO:0000269PubMed:22884692}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Widely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 126 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	126 [view]
Protein-Protein	126 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0034450	ubiquitin-ubiquitin ligase activity
GO:0043130	ubiquitin binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0006281	DNA repair
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006974	cellular response to DNA damage stimulus
GO:0008283	cell proliferation
GO:0033160	positive regulation of protein import into nucleus, translocation
GO:0035413	positive regulation of catenin import into nucleus
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0050847	progesterone receptor signaling pathway
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:1901315	negative regulation of histone H2A K63-linked ubiquitination
GO:2000780	negative regulation of double-strand break repair

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000569 HECT
IPR002004 Polyadenylate-binding protein/Hyperplastic disc protein
IPR003126 Zinc finger, N-recognin
IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
IPR013993 Zinc finger, N-recognin, metazoa
IPR024725 E3 ubiquitin ligase EDD, ubiquitin-associated domain

PFAM

PF00632
PF00658
PF02207
PF11547

PRINTS

PIRSF

SMART

SM00119
SM00517
SM00396

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O95071