InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LSS

Summary

InnateDB Protein

IDBP-479236.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LSS

Protein Name

lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)

Synonyms

OSC;

Species

Homo sapiens

Ensembl Protein

ENSP00000429133

InnateDB Gene

IDBG-6269 (LSS)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000250	lanosterol synthase activity
GO:0003824	catalytic activity
GO:0016866	intramolecular transferase activity

Biological Process

GO:0006695	cholesterol biosynthetic process
GO:0008202	steroid metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0005811	lipid particle
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001330 Prenyltransferase/squalene oxidase
IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
IPR018333 Squalene cyclase

PFAM

PF00432

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P48449

PhosphoSite

PhosphoSite-P48449

TrEMBL

UniProt Splice Variant

Entrez Gene

4047

UniGene

Hs.734274

RefSeq

NP_001138908

HUGO

HGNC:6708

OMIM

600909

CCDS

CCDS46654

HPRD

02945

IMGT

EMBL

AJ239021 AJ239022 AJ239023 AJ239024 AJ239025 AJ239026 AJ239027 AJ239028 AJ239029 AJ239030 AJ239031 AK226141 AK296313 AP001468 AP001469 BC035638 CH471079 D63807 S81221 U22526 X87809

GenPept

AAB36220 AAC50184 AAH35638 BAA09875 BAG59011 CAA61078 CAB42828 EAX09299 EAX09301 EAX09302 EAX09303