InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: APC

Summary

InnateDB Protein

IDBP-479430.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APC

Protein Name

adenomatous polyposis coli

Synonyms

BTPS2; DP2; DP2.5; DP3; GS; PPP1R46;

Species

Homo sapiens

Ensembl Protein

ENSP00000423828

InnateDB Gene

IDBG-37007 (APC)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 194 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.

Experimentally validated
Total	194 [view]
Protein-Protein	192 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	44 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008013	beta-catenin binding

Biological Process

GO:0006974	cellular response to DNA damage stimulus
GO:0007050	cell cycle arrest
GO:0016055	Wnt signaling pathway

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000225 Armadillo
IPR009223 Adenomatous polyposis coli protein, cysteine-rich repeat
IPR009240 Adenomatous polyposis coli protein, 15 residue repeat
IPR016024 Armadillo-type fold
IPR026831 Adenomatous polyposis coli domain

PFAM

PF00514
PF05923
PF05972
PF11414

PRINTS

PIRSF

SMART

SM00185

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite