InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IGJ

Summary

InnateDB Protein

IDBP-479703.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IGJ

Protein Name

immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides

Synonyms

IGCJ; JCH;

Species

Homo sapiens

Ensembl Protein

ENSP00000426687

InnateDB Gene

IDBG-22626 (IGJ)

Protein Structure

UniProt Annotation

Function

Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003697	single-stranded DNA binding
GO:0003823	antigen binding
GO:0019862	IgA binding
GO:0031210	phosphatidylcholine binding
GO:0034987	immunoglobulin receptor binding
GO:0042803	protein homodimerization activity
GO:0042834	peptidoglycan binding

Biological Process

GO:0001895	retina homeostasis
GO:0002250	adaptive immune response
GO:0003094	glomerular filtration
GO:0006955	immune response
GO:0019731	antibacterial humoral response
GO:0032461	positive regulation of protein oligomerization
GO:0045087	innate immune response
GO:0060267	positive regulation of respiratory burst

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0070062	extracellular vesicular exosome
GO:0071748	monomeric IgA immunoglobulin complex
GO:0071750	dimeric IgA immunoglobulin complex
GO:0071751	secretory IgA immunoglobulin complex
GO:0071752	secretory dimeric IgA immunoglobulin complex
GO:0071756	pentameric IgM immunoglobulin complex
GO:0072562	blood microparticle