InnateDB Protein
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IDBP-479706.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SEPT11
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Protein Name
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septin 11
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000422896
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InnateDB Gene
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IDBG-25655 (SEPT11)
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Protein Structure
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Function |
Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy. {ECO:0000250, ECO:0000269PubMed:15196925, ECO:0000269PubMed:19234302, ECO:0000305}.
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Subcellular Localization |
Cytoplasm, cytoskeleton. Cell junction, synapse. Cell projection, dendritic spine. Cell projection, axon {ECO:0000250}. Note=Partly colocalizes with stress fibers and microtubules. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria.
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Disease Associations |
Note=A chromosomal aberration involving SEPT11 may be a cause of chronic neutrophilic leukemia. Translocation t(4;11)(q21;q23) with KMT2A/MLL1.
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Tissue Specificity |
Widely expressed, except in leukocytes. {ECO:0000269PubMed:15196925, ECO:0000269PubMed:15915442}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
33
[view]
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Protein-Protein |
33
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000038
Cell division protein GTP binding
IPR016491
Septin
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF00735
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PRINTS |
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PIRSF |
PIRSF006698
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NVA2
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PhosphoSite |
PhosphoSite-Q9NVA2
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TrEMBL |
D6RDU5
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UniProt Splice Variant |
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Entrez Gene |
55752
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UniGene |
Hs.635257
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RefSeq |
XP_005263178
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HUGO |
HGNC:25589
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OMIM |
612887
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CCDS |
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HPRD |
08555
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IMGT |
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EMBL |
AC104687
AC111196
AK001711
AK027633
AK302700
AL110300
BC008083
BC063615
CH471057
GU727629
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GenPept |
AAH08083
AAH63615
AAY40922
ADU87631
BAA91853
BAB55250
BAH13782
CAB53741
EAX05805
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