Homo sapiens Protein: PLK4 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-480442.3 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | PLK4 | ||||||||||||||||||||||
Protein Name | polo-like kinase 4 | ||||||||||||||||||||||
Synonyms | SAK; STK18; | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000423582 | ||||||||||||||||||||||
InnateDB Gene | IDBG-37545 (PLK4) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. {ECO:0000269PubMed:16244668, ECO:0000269PubMed:16326102, ECO:0000269PubMed:17681131, ECO:0000269PubMed:18239451, ECO:0000269PubMed:19164942, ECO:0000269PubMed:21725316}. | ||||||||||||||||||||||
Subcellular Localization | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus, nucleolus {ECO:0000250}. Cleavage furrow. Note=Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Associates with centrioles throughout the cell cycle. According to PubMed:16244668, it is not present at cleavage furrows. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | |||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR000719
Protein kinase domain IPR000959 POLO box duplicated domain IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain IPR011009 Protein kinase-like domain IPR020635 Tyrosine-protein kinase, catalytic domain |
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PFAM |
PF00069
PF00659 PF07714 |
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PRINTS |
PR00109
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PIRSF | |||||||||||||||||||||||
SMART |
SM00220
SM00219 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | O00444 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-O00444 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 10733 | ||||||||||||||||||||||
UniGene | Hs.604902 | ||||||||||||||||||||||
RefSeq | NP_001177730 | ||||||||||||||||||||||
HUGO | HGNC:11397 | ||||||||||||||||||||||
OMIM | 605031 | ||||||||||||||||||||||
CCDS | CCDS54804 | ||||||||||||||||||||||
HPRD | 10387 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AB006972 AK302858 AK303399 AK314238 BC036023 Y13115 | ||||||||||||||||||||||
GenPept | AAH36023 BAB69958 BAG36907 BAH13823 BAH13953 CAA73575 | ||||||||||||||||||||||