Homo sapiens Gene: PLK4
Summary
InnateDB Gene IDBG-37545.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLK4
Gene Name polo-like kinase 4
Synonyms SAK; STK18;
Species Homo sapiens
Ensembl Gene ENSG00000142731
Encoded Proteins
polo-like kinase 4
polo-like kinase 4
polo-like kinase 4
polo-like kinase 4
polo-like kinase 4
polo-like kinase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:127880861-127899195
Strand Forward strand
Band q28.1
Transcripts
ENST00000270861 ENSP00000270861
ENST00000511942
ENST00000503914
ENST00000515069 ENSP00000421774
ENST00000513090 ENSP00000427554
ENST00000507249 ENSP00000423412
ENST00000514379 ENSP00000423582
ENST00000510605
ENST00000507454
ENST00000508113 ENSP00000427568
ENST00000510192
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 19 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 5 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0042802 identical protein binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0006468 protein phosphorylation
GO:0007099 centriole replication
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0046601 positive regulation of centriole replication
GO:0060707 trophoblast giant cell differentiation
GO:0098535 de novo centriole assembly
Cellular Component
GO:0005730 nucleolus
GO:0005813 centrosome
GO:0005814 centriole
GO:0005829 cytosol
GO:0032154 cleavage furrow
GO:0098536 deuterosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Loss of Nlp from mitotic centrosomes pathway
Recruitment of mitotic centrosome proteins and complexes pathway
Regulation of PLK1 Activity at G2/M Transition pathway
Cell Cycle pathway
Centrosome maturation pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Loss of proteins required for interphase microtubule organization√?¬†from the centrosome pathway
Mitotic G2-G2/M phases pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Polo-like kinase signaling events in the cell cycle
PLK2 and PLK4 events
Cross-References
SwissProt
TrEMBL J3KR84
UniProt Splice Variant
Entrez Gene 10733
UniGene Hs.172052 Hs.595187 Hs.604902
RefSeq NM_014264 NM_001190799 NM_001190801 XM_006714071
HUGO HGNC:11397
OMIM 605031
CCDS CCDS3735 CCDS54803 CCDS54804
HPRD 10387
IMGT
EMBL AC107053
GenPept
RNA Seq Atlas 10733