InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DAPK1

Summary

InnateDB Protein

IDBP-480806.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DAPK1

Protein Name

death-associated protein kinase 1

Synonyms

DAPK;

Species

Homo sapiens

Ensembl Protein

ENSP00000419026

InnateDB Gene

IDBG-74918 (DAPK1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	51 [view]
Protein-Protein	46 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004683	calmodulin-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0042802	identical protein binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0009103	lipopolysaccharide biosynthetic process
GO:0010506	regulation of autophagy
GO:0017148	negative regulation of translation
GO:0035556	intracellular signal transduction
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0046777	protein autophosphorylation
GO:0071346	cellular response to interferon-gamma
GO:0097190	apoptotic signaling pathway
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity

Cellular Component

GO:0005737	cytoplasm
GO:0015629	actin cytoskeleton
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000488 Death domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002110 Ankyrin repeat
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR010440 Lipopolysaccharide kinase
IPR011009 Protein kinase-like domain
IPR011029 Death-like domain
IPR018934 RIO-like kinase
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR020683 Ankyrin repeat-containing domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM