Version 5.4
Homo sapiens Gene: DAPK1
Summary
InnateDB Gene IDBG-74918.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DAPK1
Gene Name death-associated protein kinase 1
Synonyms DAPK;
Species Homo sapiens
Ensembl Gene ENSG00000196730
Encoded Proteins
IDBP-74924
death-associated protein kinase 1
IDBP-293165
death-associated protein kinase 1
IDBP-478941
death-associated protein kinase 1
IDBP-480806
death-associated protein kinase 1
IDBP-484233
death-associated protein kinase 1
IDBP-477947
death-associated protein kinase 1
IDBP-810723
death-associated protein kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. [provided by RefSeq, Jul 2008]
Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:87497228-87708633
Strand Forward strand
Band q21.33
Transcripts
ENST00000358077 ENSP00000350785
ENST00000408954 ENSP00000386135
ENST00000472284 ENSP00000417076
ENST00000469067
ENST00000495182
ENST00000470267
ENST00000496522
ENST00000472344
ENST00000491893 ENSP00000419026
ENST00000489291 ENSP00000417746
ENST00000463069
ENST00000475804
ENST00000495281
ENST00000494010
ENST00000466188
ENST00000497743
ENST00000468482
ENST00000469640 ENSP00000418885
ENST00000622514 ENSP00000484267
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 51 [view]
Protein-Protein 46 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004683 calmodulin-dependent protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0042802 identical protein binding
Biological Process
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0009103 lipopolysaccharide biosynthetic process
GO:0010506 regulation of autophagy
GO:0017148 negative regulation of translation
GO:0035556 intracellular signal transduction
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0046777 protein autophosphorylation
GO:0071346 cellular response to interferon-gamma
GO:0097190 apoptotic signaling pathway
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity
Cellular Component
GO:0005737 cytoplasm
GO:0015629 actin cytoskeleton
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSMUSG00000021559
View Gene Order
Ortholuge
SSD Ortholog
Ortholog supports species divergence
ENSBTAG00000000738
Not yet available
Ortholuge
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
REACT_578
Apoptosis pathway
REACT_22128
Role of DCC in regulating apoptosis pathway
REACT_13648
Regulation of Apoptosis pathway
KEGG
hsa05200
Pathways in cancer pathway
hsa05219
Bladder cancer pathway
INOH
PID BIOCARTA
PID NCI
netrin_pathway
Netrin-mediated signaling events
ifngpathway
IFN-gamma pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.380277
RefSeq NM_001288729 NM_001288730 NM_001288731 NM_004938 XM_005251757 XM_006716988
HUGO
OMIM
CCDS CCDS43842
HPRD 02902
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca