InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VEGFA

Summary

InnateDB Protein

IDBP-480813.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VEGFA

Protein Name

vascular endothelial growth factor A

Synonyms

MVCD1; VEGF; VPF;

Species

Homo sapiens

Ensembl Protein

ENSP00000430002

InnateDB Gene

IDBG-88716 (VEGFA)

Protein Structure

UniProt Annotation

Function

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. {ECO:0000269PubMed:11427521, ECO:0000269PubMed:16489009}.

Subcellular Localization

Secreted {ECO:0000269PubMed:11563986, ECO:0000269PubMed:11731620, ECO:0000269PubMed:15896327}. Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.

Disease Associations

Microvascular complications of diabetes 1 (MVCD1) [MIM:603933]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end- stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed. A higher level expression seen in pituitary tumors as compared to the pituitary gland. {ECO:0000269PubMed:22009797}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 59 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	59 [view]
Protein-Protein	39 [view]
Protein-DNA	18 [view]
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001968	fibronectin binding
GO:0005125	cytokine activity
GO:0005161	platelet-derived growth factor receptor binding
GO:0005172	vascular endothelial growth factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0008201	heparin binding
GO:0038191	neuropilin binding
GO:0042056	chemoattractant activity
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0043183	vascular endothelial growth factor receptor 1 binding
GO:0043184	vascular endothelial growth factor receptor 2 binding
GO:0046982	protein heterodimerization activity
GO:0048018	receptor agonist activity
GO:0050840	extracellular matrix binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001525	angiogenesis
GO:0001541	ovarian follicle development
GO:0001569	patterning of blood vessels
GO:0001570	vasculogenesis
GO:0001666	response to hypoxia
GO:0001701	in utero embryonic development
GO:0001822	kidney development
GO:0001934	positive regulation of protein phosphorylation
GO:0001938	positive regulation of endothelial cell proliferation
GO:0002042	cell migration involved in sprouting angiogenesis
GO:0002052	positive regulation of neuroblast proliferation
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0002092	positive regulation of receptor internalization
GO:0002575	basophil chemotaxis
GO:0002576	platelet degranulation
GO:0002687	positive regulation of leukocyte migration
GO:0003007	heart morphogenesis
GO:0003151	outflow tract morphogenesis
GO:0003169	coronary vein morphogenesis
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007399	nervous system development
GO:0007498	mesoderm development
GO:0007595	lactation
GO:0007596	blood coagulation
GO:0008284	positive regulation of cell proliferation
GO:0008360	regulation of cell shape
GO:0010595	positive regulation of endothelial cell migration
GO:0010628	positive regulation of gene expression
GO:0030168	platelet activation
GO:0030224	monocyte differentiation
GO:0030225	macrophage differentiation
GO:0030324	lung development
GO:0030335	positive regulation of cell migration
GO:0030855	epithelial cell differentiation
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031077	post-embryonic camera-type eye development
GO:0031334	positive regulation of protein complex assembly
GO:0031954	positive regulation of protein autophosphorylation
GO:0032147	activation of protein kinase activity
GO:0032793	positive regulation of CREB transcription factor activity
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0035148	tube formation
GO:0035767	endothelial cell chemotaxis
GO:0035924	cellular response to vascular endothelial growth factor stimulus
GO:0036303	lymph vessel morphogenesis
GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0038084	vascular endothelial growth factor signaling pathway
GO:0038091	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0038190	VEGF-activated neuropilin signaling pathway
GO:0040007	growth
GO:0042462	eye photoreceptor cell development
GO:0043066	negative regulation of apoptotic process
GO:0043117	positive regulation of vascular permeability
GO:0043129	surfactant homeostasis
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043406	positive regulation of MAP kinase activity
GO:0043536	positive regulation of blood vessel endothelial cell migration
GO:0045087	innate immune response (InnateDB)
GO:0045766	positive regulation of angiogenesis
GO:0045785	positive regulation of cell adhesion
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0048469	cell maturation
GO:0048593	camera-type eye morphogenesis
GO:0048739	cardiac muscle fiber development
GO:0048754	branching morphogenesis of an epithelial tube
GO:0048842	positive regulation of axon extension involved in axon guidance
GO:0048844	artery morphogenesis
GO:0050679	positive regulation of epithelial cell proliferation
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918	positive chemotaxis
GO:0050927	positive regulation of positive chemotaxis
GO:0050930	induction of positive chemotaxis
GO:0051272	positive regulation of cellular component movement
GO:0051781	positive regulation of cell division
GO:0051894	positive regulation of focal adhesion assembly
GO:0060319	primitive erythrocyte differentiation
GO:0060749	mammary gland alveolus development
GO:0060754	positive regulation of mast cell chemotaxis
GO:0060948	cardiac vascular smooth muscle cell development
GO:0060982	coronary artery morphogenesis
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071456	cellular response to hypoxia
GO:0071542	dopaminergic neuron differentiation
GO:0071679	commissural neuron axon guidance
GO:0090037	positive regulation of protein kinase C signaling
GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis
GO:0090259	regulation of retinal ganglion cell axon guidance
GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation
GO:1900745	positive regulation of p38MAPK cascade
GO:1901727	positive regulation of histone deacetylase activity
GO:1902336	positive regulation of retinal ganglion cell axon guidance
GO:1902533	positive regulation of intracellular signal transduction
GO:1902966	positive regulation of protein localization to early endosome

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0009986	cell surface
GO:0016020	membrane
GO:0030141	secretory granule
GO:0031093	platelet alpha granule lumen