Version 5.4
Homo sapiens Gene: VEGFA
Summary
InnateDB Gene IDBG-88716.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VEGFA
Gene Name vascular endothelial growth factor A
Synonyms MVCD1; VEGF; VPF
Species Homo sapiens
Ensembl Gene ENSG00000112715
Encoded Proteins
IDBP-88718
vascular endothelial growth factor A
IDBP-88720
vascular endothelial growth factor A
IDBP-88724
vascular endothelial growth factor A
IDBP-88726
vascular endothelial growth factor A
IDBP-88728
vascular endothelial growth factor A
IDBP-88732
vascular endothelial growth factor A
IDBP-380323
vascular endothelial growth factor A
IDBP-380324
vascular endothelial growth factor A
IDBP-380325
vascular endothelial growth factor A
IDBP-380328
vascular endothelial growth factor A
IDBP-484650
vascular endothelial growth factor A
IDBP-480596
vascular endothelial growth factor A
IDBP-478114
vascular endothelial growth factor A
IDBP-474923
vascular endothelial growth factor A
IDBP-477771
vascular endothelial growth factor A
IDBP-483858
vascular endothelial growth factor A
IDBP-480813
vascular endothelial growth factor A
IDBP-477074
vascular endothelial growth factor A
IDBP-480969
vascular endothelial growth factor A
IDBP-808888
vascular endothelial growth factor A
IDBP-808889
vascular endothelial growth factor A
IDBP-808890
vascular endothelial growth factor A
IDBP-808891
vascular endothelial growth factor A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21278304
VEGFA-induced tissue response, e.g. angiogenesis, is inhibited during RSV and Influenza viral infections. These effects were mediated by RIG-I and IFNR-dependent pathways, and consequently inhibited the Th2 inflammation response.
InnateDB Annotation from Orthologs
Summary
PMID 21278304
[Mus musculus] Vegfa-induced tissue response, e.g. angiogenesis, is inhibited during RSV and Influenza viral infections. These effects were mediated by RIG-I and IFNR-dependent pathways, and consequently inhibited the Th2 inflammation response.
Entrez Gene
Summary This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:43770184-43786487
Strand Forward strand
Band p21.1
Transcripts
ENST00000372055 ENSP00000361125
ENST00000324450 ENSP00000317598
ENST00000372067 ENSP00000361137
ENST00000372077 ENSP00000361148
ENST00000372064 ENSP00000361134
ENST00000230480 ENSP00000230480
ENST00000457104 ENSP00000409911
ENST00000413642 ENSP00000389864
ENST00000425836 ENSP00000388465
ENST00000417285 ENSP00000388663
ENST00000476772
ENST00000482630 ENSP00000421561
ENST00000519767 ENSP00000430594
ENST00000520948 ENSP00000428321
ENST00000518538
ENST00000523950 ENSP00000429643
ENST00000523873 ENSP00000430479
ENST00000512683
ENST00000518689 ENSP00000430829
ENST00000518824 ENSP00000430002
ENST00000523125 ENSP00000429008
ENST00000480614
ENST00000520265 ENSP00000429592
ENST00000497139
ENST00000493786
ENST00000611736 ENSP00000478570
ENST00000621747 ENSP00000483241
ENST00000615393 ENSP00000478034
ENST00000617771 ENSP00000484284
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 59 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 59 [view]
Protein-Protein 39 [view]
Protein-DNA 18 [view]
Protein-RNA 2 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001968 fibronectin binding
GO:0005102 receptor binding
GO:0005125 cytokine activity
GO:0005161 platelet-derived growth factor receptor binding
GO:0005172 vascular endothelial growth factor receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0038191 neuropilin binding
GO:0042056 chemoattractant activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043183 vascular endothelial growth factor receptor 1 binding
GO:0043184 vascular endothelial growth factor receptor 2 binding
GO:0046982 protein heterodimerization activity
GO:0048018 receptor agonist activity
GO:0050840 extracellular matrix binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001525 angiogenesis
GO:0001541 ovarian follicle development
GO:0001568 blood vessel development
GO:0001569 patterning of blood vessels
GO:0001570 vasculogenesis
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0001822 kidney development
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001944 vasculature development
GO:0002040 sprouting angiogenesis
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0002052 positive regulation of neuroblast proliferation
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002092 positive regulation of receptor internalization
GO:0002575 basophil chemotaxis
GO:0002576 platelet degranulation
GO:0002687 positive regulation of leukocyte migration
GO:0003007 heart morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003169 coronary vein morphogenesis
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007399 nervous system development
GO:0007498 mesoderm development
GO:0007595 lactation
GO:0007596 blood coagulation
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008360 regulation of cell shape
GO:0010595 positive regulation of endothelial cell migration
GO:0010628 positive regulation of gene expression
GO:0016477 cell migration
GO:0030168 platelet activation
GO:0030224 monocyte differentiation
GO:0030225 macrophage differentiation
GO:0030324 lung development
GO:0030335 positive regulation of cell migration
GO:0030855 epithelial cell differentiation
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031077 post-embryonic camera-type eye development
GO:0031334 positive regulation of protein complex assembly
GO:0031954 positive regulation of protein autophosphorylation
GO:0032147 activation of protein kinase activity
GO:0032793 positive regulation of CREB transcription factor activity
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035148 tube formation
GO:0035767 endothelial cell chemotaxis
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0036303 lymph vessel morphogenesis
GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0038084 vascular endothelial growth factor signaling pathway
GO:0038091 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0038190 VEGF-activated neuropilin signaling pathway
GO:0040007 growth
GO:0042462 eye photoreceptor cell development
GO:0043066 negative regulation of apoptotic process
GO:0043117 positive regulation of vascular permeability
GO:0043129 surfactant homeostasis
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043406 positive regulation of MAP kinase activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045087 innate immune response (InnateDB)
GO:0045766 positive regulation of angiogenesis
GO:0045785 positive regulation of cell adhesion
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048469 cell maturation
GO:0048514 blood vessel morphogenesis
GO:0048593 camera-type eye morphogenesis
GO:0048666 neuron development
GO:0048739 cardiac muscle fiber development
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048842 positive regulation of axon extension involved in axon guidance
GO:0048844 artery morphogenesis
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918 positive chemotaxis
GO:0050927 positive regulation of positive chemotaxis
GO:0050930 induction of positive chemotaxis
GO:0051272 positive regulation of cellular component movement
GO:0051781 positive regulation of cell division
GO:0051894 positive regulation of focal adhesion assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0060319 primitive erythrocyte differentiation
GO:0060426 lung vasculature development
GO:0060749 mammary gland alveolus development
GO:0060754 positive regulation of mast cell chemotaxis
GO:0060948 cardiac vascular smooth muscle cell development
GO:0060982 coronary artery morphogenesis
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071456 cellular response to hypoxia
GO:0071542 dopaminergic neuron differentiation
GO:0071679 commissural neuron axon guidance
GO:0090037 positive regulation of protein kinase C signaling
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:0090259 regulation of retinal ganglion cell axon guidance
GO:1900086 positive regulation of peptidyl-tyrosine autophosphorylation
GO:1900745 positive regulation of p38MAPK cascade
GO:1901492 positive regulation of lymphangiogenesis
GO:1901727 positive regulation of histone deacetylase activity
GO:1902336 positive regulation of retinal ganglion cell axon guidance
GO:1902533 positive regulation of intracellular signal transduction
GO:1902966 positive regulation of protein localization to early endosome
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0009986 cell surface
GO:0016020 membrane
GO:0030141 secretory granule
GO:0031093 platelet alpha granule lumen
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023951
View Gene Order
ENSBTAG00000005339
Not yet available
Pathways
NETPATH
REACTOME
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_12583
VEGF binds to VEGFR leading to receptor dimerization pathway
REACT_12380
VEGF ligand-receptor interactions pathway
REACT_121092
Regulation of gene expression by Hypoxia-inducible Factor pathway
REACT_120956
Cellular responses to stress pathway
REACT_12529
Signaling by VEGF pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_111102
Signal Transduction pathway
REACT_120815
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
REACT_121311
Cellular response to hypoxia pathway
REACT_604
Hemostasis pathway
KEGG
hsa04150
mTOR signaling pathway pathway
hsa04370
VEGF signaling pathway pathway
hsa05211
Renal cell carcinoma pathway
hsa05219
Bladder cancer pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04510
Focal adhesion pathway
hsa05212
Pancreatic cancer pathway
hsa05200
Pathways in cancer pathway
INOH
INOH website
VEGF signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
vegf_vegfr_pathway
VEGF and VEGFR signaling network
integrin1_pathway
Beta1 integrin cell surface interactions
s1p_s1p1_pathway
S1P1 pathway
avb3_integrin_pathway
Integrins in angiogenesis
glypican_1pathway
Glypican 1 network
integrin_a9b1_pathway
Alpha9 beta1 integrin signaling events
plexind1_pathway
Plexin-D1 Signaling
hif2pathway
HIF-2-alpha transcription factor network
tcptp_pathway
Signaling events mediated by TCPTP
s1p_s1p3_pathway
S1P3 pathway
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
hif1_tfpathway
HIF-1-alpha transcription factor network
shp2_pathway
SHP2 signaling
integrin3_pathway
Beta3 integrin cell surface interactions
vegfr1_pathway
VEGFR1 specific signals
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.644747 Hs.732505
RefSeq NM_001025366 NM_001025367 NM_001025368 NM_001025369 NM_001025370 NM_001033756 NM_001171622 NM_001171623 NM_001171624 NM_001171625 NM_001171626 NM_001171627 NM_001171628 NM_001171629 NM_001171630 NM_001204384 NM_001204385 NM_001287044 NM_003376
HUGO
OMIM
CCDS CCDS34457 CCDS34458 CCDS47432 CCDS47433 CCDS47434 CCDS47435 CCDS4907 CCDS55007 CCDS55008 CCDS55009 CCDS55010 CCDS55011 CCDS55012 CCDS55013 CCDS55014 CCDS55015 CCDS69125
HPRD 01889
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca