InnateDB Protein
|
IDBP-480815.3
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
SPAM1
|
Protein Name
|
sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
|
Synonyms
|
HEL-S-96n; HYA1; HYAL1; HYAL3; HYAL5; PH-20; PH20; SPAG15;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000417934
|
InnateDB Gene
|
IDBG-39033 (SPAM1)
|
Protein Structure
|
|
Function |
Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid. {ECO:0000269PubMed:8282124}.
|
Subcellular Localization |
Cell membrane; Lipid-anchor, GPI-anchor.
|
Disease Associations |
|
Tissue Specificity |
Testis. {ECO:0000269PubMed:8234258}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
|
Molecular Function |
Accession |
GO Term |
GO:0004415
|
hyalurononglucosaminidase activity
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR017853
Glycoside hydrolase, superfamily
IPR018155
Hyaluronidase
|
PFAM |
PF01630
|
PRINTS |
PR00846
|
PIRSF |
PIRSF038193
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P38567
|
PhosphoSite |
PhosphoSite-P38567
|
TrEMBL |
Q5D1J4
|
UniProt Splice Variant |
|
Entrez Gene |
6677
|
UniGene |
Hs.642293
|
RefSeq |
NP_694859
|
HUGO |
HGNC:11217
|
OMIM |
600930
|
CCDS |
CCDS5791
|
HPRD |
02958
|
IMGT |
|
EMBL |
AC004690
AK292229
AY920278
AY920279
AY920280
AY920281
BC026163
CH236947
CH471070
EU794686
L13781
S67798
X84347
|
GenPept |
AAC60607
AAH26163
AAQ96882
AAX13985
AAX13986
AAX13987
AAX13988
ACJ13740
BAF84918
CAA59086
EAL24329
EAL24330
EAW83604
EAW83606
|
|
|