Version 5.4
Homo sapiens Protein: CD74
Summary
InnateDB Protein IDBP-480953.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD74
Protein Name CD74 molecule, major histocompatibility complex, class II invariant chain
Synonyms DHLAG; HLADG; Ia-GAMMA; II;
Species Homo sapiens
Ensembl Protein ENSP00000429641
InnateDB Gene IDBG-53594 (CD74)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 13 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0042289 MHC class II protein binding
Biological Process
GO:0006886 intracellular protein transport
GO:0006955 immune response
GO:0019882 antigen processing and presentation
Cellular Component
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR015386 MHC class II-associated invariant chain/CLIP, MHC II-interacting
IPR022339 MHC class II-associated invariant chain
PFAM PF09307
PRINTS PR01990
PIRSF PIRSF001992
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL O19685
UniProt Splice Variant
Entrez Gene 972
UniGene Hs.436568
RefSeq
HUGO HGNC:1697
OMIM 142790
CCDS
HPRD 00825
IMGT
EMBL AC011372 AC011388 M28588
GenPept AAA58655

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca