InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NAT1

Summary

InnateDB Protein

IDBP-481032.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NAT1

Protein Name

N-acetyltransferase 1 (arylamine N-acetyltransferase)

Synonyms

AAC1; MNAT; NAT-1; NATI;

Species

Homo sapiens

Ensembl Protein

ENSP00000429341

InnateDB Gene

IDBG-9082 (NAT1)

Protein Structure

UniProt Annotation

Function

Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004060	arylamine N-acetyltransferase activity
GO:0016407	acetyltransferase activity

Biological Process

GO:0006805	xenobiotic metabolic process
GO:0008152	metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR001447 Arylamine N-acetyltransferase

PFAM

PF00797

PRINTS

PR01543

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-P18440

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AF008204 AF032677 AF032678 AF067408 AF071552 AF082903 AF082904 AJ278017 AJ307007 AJ581135 AJ581136 AJ581137 AJ581138 AJ581139 AJ581140 AJ581141 AJ581142 AJ581143 AK290912 AY338489 AY376850 AY730684 AY800271 BC047666 D90041 DQ305816 DQ305817 DQ305818 DQ305819 DQ305820 DQ305821 DQ305822 DQ305823 DQ305824 DQ305825 DQ305826 DQ305827 DQ305828 DQ305829 DQ305830 DQ305831 DQ305832 DQ305833 DQ305834 DQ305835 DQ305836 DQ305837 DQ305838 DQ305839 DQ305840 DQ305841 DQ305842 DQ305843 DQ305844 DQ305845 DQ305846 DQ305847 DQ305848 DQ305849 DQ305850 DQ305851 DQ305852 DQ305853 DQ305854 DQ305855 DQ305856 DQ305857 DQ305858 DQ305859 DQ305860 DQ305861 DQ305862 DQ305863 DQ305864 DQ305865 DQ305866 DQ305867 DQ305868 DQ305869 DQ305870 DQ305871 DQ305872 DQ305873 DQ305874 DQ305875 DQ305876 DQ305877 DQ305878 DQ305879 DQ305880 DQ305881 DQ305882 DQ305883 DQ305884 DQ305885 DQ305886 DQ305887 DQ305888 DQ305889 DQ305890 DQ305891 DQ305892 DQ305893 DQ305894 DQ305895 DQ305896 DQ305897 DQ305898 DQ305899 DQ305900 DQ305901 DQ305902 DQ305903 DQ305904 DQ305905 DQ305906 DQ305907 DQ305908 DQ305909 DQ305910 DQ305911 DQ305912 DQ305913 DQ305914 DQ305915 DQ305916 DQ305917 DQ305918 DQ305919 DQ305920 DQ305921 DQ305922 DQ305923 DQ305924 DQ305925 DQ305926 DQ305927 DQ305928 DQ305929 DQ305930 DQ305931 DQ305932 DQ305933 DQ305934 DQ305935 DQ305936 DQ305937 DQ305938 DQ305939 DQ305940 DQ305941 DQ305942 DQ305943 DQ305944 DQ305945 DQ305946 DQ305947 DQ305948 DQ305949 DQ305950 DQ305951 DQ305952 DQ305953 DQ305954 DQ305955 DQ305956 DQ305957 DQ305958 DQ305959 DQ305960 DQ305961 DQ305962 DQ305963 DQ305964 DQ305965 DQ305966 DQ305967 DQ305968 DQ305969 DQ305970 DQ305971 DQ305972 DQ305973 DQ305974 DQ305975 DQ871603 M75164 U80835 X17059

GenPept

AAA59905 AAB62398 AAB84384 AAB86878 AAB86879 AAC24707 AAC24712 AAC32388 AAD13343 AAH47666 AAP88036 AAQ74989 AAV50002 AAX22230 ABC26192 ABC26193 ABC26194 ABC26195 ABC26196 ABC26197 ABC26198 ABC26199 ABC26200 ABC26201 ABC26202 ABC26203 ABC26204 ABC26205 ABC26206 ABC26207 ABC26208 ABC26209 ABC26210 ABC26211 ABC26212 ABC26213 ABC26214 ABC26215 ABC26216 ABC26217 ABC26218 ABC26219 ABC26220 ABC26221 ABC26222 ABC26223 ABC26224 ABC26225 ABC26226 ABC26227 ABC26228 ABC26229 ABC26230 ABC26231 ABC26232 ABC26233 ABC26234 ABC26235 ABC26236 ABC26237 ABC26238 ABC26239 ABC26240 ABC26241 ABC26242 ABC26243 ABC26244 ABC26245 ABC26246 ABC26247 ABC26248 ABC26249 ABC26250 ABC26251 ABC26252 ABC26253 ABC26254 ABC26255 ABC26256 ABC26257 ABC26258 ABC26259 ABC26260 ABC26261 ABC26262 ABC26263 ABC26264 ABC26265 ABC26266 ABC26267 ABC26268 ABC26269 ABC26270 ABC26271 ABC26272 ABC26273 ABC26274 ABC26275 ABC26276 ABC26277 ABC26278 ABC26279 ABC26280 ABC26281 ABC26282 ABC26283 ABC26284 ABC26285 ABC26286 ABC26287 ABC26288 ABC26289 ABC26290 ABC26291 ABC26292 ABC26293 ABC26294 ABC26295 ABC26296 ABC26297 ABC26298 ABC26299 ABC26300 ABC26301 ABC26302 ABC26303 ABC26304 ABC26305 ABC26306 ABC26307 ABC26308 ABC26309 ABC26310 ABC26311 ABC26312 ABC26313 ABC26314 ABC26315 ABC26316 ABC26317 ABC26318 ABC26319 ABC26320 ABC26321 ABC26322 ABC26323 ABC26324 ABC26325 ABC26326 ABC26327 ABC26328 ABC26329 ABC26330 ABC26331 ABC26332 ABC26333 ABC26334 ABC26335 ABC26336 ABC26337 ABC26338 ABC26339 ABC26340 ABC26341 ABC26342 ABC26343 ABC26344 ABC26345 ABC26346 ABC26347 ABC26348 ABC26349 ABC26350 ABC26351 ABI49510 BAA14095 BAF83601 CAA34905 CAC01128 CAC38345 CAE46162 CAE46163 CAE46164 CAE46165 CAE46166 CAE46167 CAE46168 CAE46169 CAE46170

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca