Homo sapiens Gene: NAT1
Summary
InnateDB Gene IDBG-9082.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NAT1
Gene Name N-acetyltransferase 1 (arylamine N-acetyltransferase)
Synonyms AAC1; MNAT; NAT-1; NATI;
Species Homo sapiens
Ensembl Gene ENSG00000171428
Encoded Proteins
N-acetyltransferase 1 (arylamine N-acetyltransferase)
N-acetyltransferase 1 (arylamine N-acetyltransferase)
N-acetyltransferase 1 (arylamine N-acetyltransferase)
N-acetyltransferase 1 (arylamine N-acetyltransferase)
N-acetyltransferase 1 (arylamine N-acetyltransferase)
N-acetyltransferase 1 (arylamine N-acetyltransferase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:18170477-18223689
Strand Forward strand
Band p22
Transcripts
ENST00000307719 ENSP00000307218
ENST00000517441
ENST00000518029 ENSP00000428270
ENST00000517574
ENST00000519006
ENST00000517837
ENST00000517492 ENSP00000429407
ENST00000520546 ENSP00000429341
ENST00000545197 ENSP00000443194
ENST00000541942 ENSP00000440900
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004060 arylamine N-acetyltransferase activity
GO:0016407 acetyltransferase activity
Biological Process
GO:0006805 xenobiotic metabolic process
GO:0008152 metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Phase II conjugation pathway
Acetylation pathway
Metabolism pathway
Biological oxidations pathway
KEGG
Caffeine metabolism pathway
Drug metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P18440
TrEMBL Q09LL5 Q400I9 Q400J6 Q5C8V2 Q6U7I7
UniProt Splice Variant
Entrez Gene 9
UniGene Hs.155956 Hs.591847
RefSeq NM_001160174 NM_000662 NM_001160171 NM_001160179 NM_001160170 NM_001160173 NM_001160172 NM_001160176 NM_001160175 NM_001291962 XM_006716410
HUGO HGNC:7645
OMIM 108345
CCDS CCDS6007 CCDS55205
HPRD 00149
IMGT
EMBL AF008204 AF032677 AF032678 AF067408 AF071552 AF082903 AF082904 AJ278017 AJ307007 AJ581135 AJ581136 AJ581137 AJ581138 AJ581139 AJ581140 AJ581141 AJ581142 AJ581143 AK290912 AY338489 AY376850 AY730684 AY800271 BC047666 D90041 DQ305816 DQ305817 DQ305818 DQ305819 DQ305820 DQ305821 DQ305822 DQ305823 DQ305824 DQ305825 DQ305826 DQ305827 DQ305828 DQ305829 DQ305830 DQ305831 DQ305832 DQ305833 DQ305834 DQ305835 DQ305836 DQ305837 DQ305838 DQ305839 DQ305840 DQ305841 DQ305842 DQ305843 DQ305844 DQ305845 DQ305846 DQ305847 DQ305848 DQ305849 DQ305850 DQ305851 DQ305852 DQ305853 DQ305854 DQ305855 DQ305856 DQ305857 DQ305858 DQ305859 DQ305860 DQ305861 DQ305862 DQ305863 DQ305864 DQ305865 DQ305866 DQ305867 DQ305868 DQ305869 DQ305870 DQ305871 DQ305872 DQ305873 DQ305874 DQ305875 DQ305876 DQ305877 DQ305878 DQ305879 DQ305880 DQ305881 DQ305882 DQ305883 DQ305884 DQ305885 DQ305886 DQ305887 DQ305888 DQ305889 DQ305890 DQ305891 DQ305892 DQ305893 DQ305894 DQ305895 DQ305896 DQ305897 DQ305898 DQ305899 DQ305900 DQ305901 DQ305902 DQ305903 DQ305904 DQ305905 DQ305906 DQ305907 DQ305908 DQ305909 DQ305910 DQ305911 DQ305912 DQ305913 DQ305914 DQ305915 DQ305916 DQ305917 DQ305918 DQ305919 DQ305920 DQ305921 DQ305922 DQ305923 DQ305924 DQ305925 DQ305926 DQ305927 DQ305928 DQ305929 DQ305930 DQ305931 DQ305932 DQ305933 DQ305934 DQ305935 DQ305936 DQ305937 DQ305938 DQ305939 DQ305940 DQ305941 DQ305942 DQ305943 DQ305944 DQ305945 DQ305946 DQ305947 DQ305948 DQ305949 DQ305950 DQ305951 DQ305952 DQ305953 DQ305954 DQ305955 DQ305956 DQ305957 DQ305958 DQ305959 DQ305960 DQ305961 DQ305962 DQ305963 DQ305964 DQ305965 DQ305966 DQ305967 DQ305968 DQ305969 DQ305970 DQ305971 DQ305972 DQ305973 DQ305974 DQ305975 DQ871603 M75164 U80835 X17059
GenPept AAA59905 AAB62398 AAB84384 AAB86878 AAB86879 AAC24707 AAC24712 AAC32388 AAD13343 AAH47666 AAP88036 AAQ74989 AAV50002 AAX22230 ABC26192 ABC26193 ABC26194 ABC26195 ABC26196 ABC26197 ABC26198 ABC26199 ABC26200 ABC26201 ABC26202 ABC26203 ABC26204 ABC26205 ABC26206 ABC26207 ABC26208 ABC26209 ABC26210 ABC26211 ABC26212 ABC26213 ABC26214 ABC26215 ABC26216 ABC26217 ABC26218 ABC26219 ABC26220 ABC26221 ABC26222 ABC26223 ABC26224 ABC26225 ABC26226 ABC26227 ABC26228 ABC26229 ABC26230 ABC26231 ABC26232 ABC26233 ABC26234 ABC26235 ABC26236 ABC26237 ABC26238 ABC26239 ABC26240 ABC26241 ABC26242 ABC26243 ABC26244 ABC26245 ABC26246 ABC26247 ABC26248 ABC26249 ABC26250 ABC26251 ABC26252 ABC26253 ABC26254 ABC26255 ABC26256 ABC26257 ABC26258 ABC26259 ABC26260 ABC26261 ABC26262 ABC26263 ABC26264 ABC26265 ABC26266 ABC26267 ABC26268 ABC26269 ABC26270 ABC26271 ABC26272 ABC26273 ABC26274 ABC26275 ABC26276 ABC26277 ABC26278 ABC26279 ABC26280 ABC26281 ABC26282 ABC26283 ABC26284 ABC26285 ABC26286 ABC26287 ABC26288 ABC26289 ABC26290 ABC26291 ABC26292 ABC26293 ABC26294 ABC26295 ABC26296 ABC26297 ABC26298 ABC26299 ABC26300 ABC26301 ABC26302 ABC26303 ABC26304 ABC26305 ABC26306 ABC26307 ABC26308 ABC26309 ABC26310 ABC26311 ABC26312 ABC26313 ABC26314 ABC26315 ABC26316 ABC26317 ABC26318 ABC26319 ABC26320 ABC26321 ABC26322 ABC26323 ABC26324 ABC26325 ABC26326 ABC26327 ABC26328 ABC26329 ABC26330 ABC26331 ABC26332 ABC26333 ABC26334 ABC26335 ABC26336 ABC26337 ABC26338 ABC26339 ABC26340 ABC26341 ABC26342 ABC26343 ABC26344 ABC26345 ABC26346 ABC26347 ABC26348 ABC26349 ABC26350 ABC26351 ABI49510 BAA14095 BAF83601 CAA34905 CAC01128 CAC38345 CAE46162 CAE46163 CAE46164 CAE46165 CAE46166 CAE46167 CAE46168 CAE46169 CAE46170
RNA Seq Atlas 9