Version 5.4
Homo sapiens Gene: NAT1
Summary
InnateDB Gene IDBG-9082.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NAT1
Gene Name N-acetyltransferase 1 (arylamine N-acetyltransferase)
Synonyms AAC1; MNAT; NAT-1; NATI
Species Homo sapiens
Ensembl Gene ENSG00000171428
Encoded Proteins
IDBP-9084
N-acetyltransferase 1 (arylamine N-acetyltransferase)
IDBP-482965
N-acetyltransferase 1 (arylamine N-acetyltransferase)
IDBP-475104
N-acetyltransferase 1 (arylamine N-acetyltransferase)
IDBP-481032
N-acetyltransferase 1 (arylamine N-acetyltransferase)
IDBP-590846
N-acetyltransferase 1 (arylamine N-acetyltransferase)
IDBP-584134
N-acetyltransferase 1 (arylamine N-acetyltransferase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:18170477-18223689
Strand Forward strand
Band p22
Transcripts
ENST00000307719 ENSP00000307218
ENST00000517441
ENST00000518029 ENSP00000428270
ENST00000517574
ENST00000519006
ENST00000517837
ENST00000517492 ENSP00000429407
ENST00000520546 ENSP00000429341
ENST00000545197 ENSP00000443194
ENST00000541942 ENSP00000440900
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004060 arylamine N-acetyltransferase activity
GO:0016407 acetyltransferase activity
Biological Process
GO:0006805 xenobiotic metabolic process
GO:0008152 metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000051147
View Gene Order
ENSBTAG00000016473
Not yet available
Pathways
NETPATH
REACTOME
REACT_6732
Acetylation pathway
REACT_6959
Phase II conjugation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
KEGG
hsa00232
Caffeine metabolism pathway
hsa00983
Drug metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.155956 Hs.591847
RefSeq NM_000662 NM_001160170 NM_001160171 NM_001160172 NM_001160173 NM_001160174 NM_001160175 NM_001160176 NM_001160179 NM_001291962 XM_006716410
HUGO
OMIM
CCDS CCDS55205 CCDS6007
HPRD 00149
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca