InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CANX

Summary

InnateDB Protein

IDBP-481088.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CANX

Protein Name

calnexin

Synonyms

CNX; IP90; P90;

Species

Homo sapiens

Ensembl Protein

ENSP00000424063

InnateDB Gene

IDBG-61587 (CANX)

Protein Structure

UniProt Annotation

Function

Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at the synapse.

Subcellular Localization

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. The palmitoylated form preferentially localizes to the perinuclear rough ER.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 125 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	125 [view]
Protein-Protein	124 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0051082	unfolded protein binding

Biological Process

GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0006457	protein folding
GO:0009306	protein secretion
GO:0018279	protein N-linked glycosylation via asparagine
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0048488	synaptic vesicle endocytosis
GO:0072583	clathrin-mediated endocytosis

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome
GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane