InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HPSE

Summary

InnateDB Protein

IDBP-481384.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HPSE

Protein Name

heparanase

Synonyms

HPA; HPA1; HPR1; HPSE1; HSE1;

Species

Homo sapiens

Ensembl Protein

ENSP00000423265

InnateDB Gene

IDBG-27684 (HPSE)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004566	beta-glucuronidase activity
GO:0005515	protein binding
GO:0016798	hydrolase activity, acting on glycosyl bonds
GO:0030305	heparanase activity
GO:0045545	syndecan binding
GO:0046983	protein dimerization activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006027	glycosaminoglycan catabolic process
GO:0006029	proteoglycan metabolic process
GO:0007160	cell-matrix adhesion
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0030194	positive regulation of blood coagulation
GO:0030200	heparan sulfate proteoglycan catabolic process
GO:0030203	glycosaminoglycan metabolic process
GO:0033690	positive regulation of osteoblast proliferation
GO:0044281	small molecule metabolic process
GO:0051797	regulation of hair follicle development
GO:0051897	positive regulation of protein kinase B signaling

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0016020	membrane
GO:0043202	lysosomal lumen
GO:0043231	intracellular membrane-bounded organelle