InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HPSE

Summary

InnateDB Gene

IDBG-27684.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HPSE

Gene Name

heparanase

Synonyms

HPA; HPA1; HPR1; HPSE1; HSE1

Species

Homo sapiens

Ensembl Gene

ENSG00000173083

Encoded Proteins

IDBP-27686

heparanase

IDBP-293300

heparanase

IDBP-477346

heparanase

IDBP-481384

heparanase

IDBP-482467

heparanase

IDBP-473955

heparanase

IDBP-482507

heparanase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:83292461-83335153

Strand

Reverse strand

Band

q21.23

Transcripts

ENST00000311412	ENSP00000308107
ENST00000405413	ENSP00000384262
ENST00000507150	ENSP00000426139
ENST00000512196	ENSP00000423265
ENST00000509906	ENSP00000421038
ENST00000508891	ENSP00000421827
ENST00000513463	ENSP00000421365

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004566	beta-glucuronidase activity
GO:0005515	protein binding
GO:0016798	hydrolase activity, acting on glycosyl bonds
GO:0030305	heparanase activity
GO:0045545	syndecan binding
GO:0046983	protein dimerization activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006027	glycosaminoglycan catabolic process
GO:0006029	proteoglycan metabolic process
GO:0007160	cell-matrix adhesion
GO:0008152	metabolic process
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0030194	positive regulation of blood coagulation
GO:0030200	heparan sulfate proteoglycan catabolic process
GO:0030203	glycosaminoglycan metabolic process
GO:0033690	positive regulation of osteoblast proliferation
GO:0042060	wound healing
GO:0044281	small molecule metabolic process
GO:0051797	regulation of hair follicle development
GO:0051798	positive regulation of hair follicle development
GO:0051897	positive regulation of protein kinase B signaling
GO:0060055	angiogenesis involved in wound healing
GO:0061042	vascular wound healing

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0016020	membrane
GO:0043202	lysosomal lumen
GO:0043231	intracellular membrane-bounded organelle
GO:0045121	membrane raft