Homo sapiens Gene: HPSE
Summary
InnateDB Gene IDBG-27684.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HPSE
Gene Name heparanase
Synonyms HPA; HPA1; HPR1; HPSE1; HSE1;
Species Homo sapiens
Ensembl Gene ENSG00000173083
Encoded Proteins
heparanase
heparanase
heparanase
heparanase
heparanase
heparanase
heparanase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:83292461-83335153
Strand Reverse strand
Band q21.23
Transcripts
ENST00000311412 ENSP00000308107
ENST00000405413 ENSP00000384262
ENST00000507150 ENSP00000426139
ENST00000512196 ENSP00000423265
ENST00000509906 ENSP00000421038
ENST00000508891 ENSP00000421827
ENST00000513463 ENSP00000421365
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004566 beta-glucuronidase activity
GO:0005515 protein binding
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0030305 heparanase activity
GO:0045545 syndecan binding
GO:0046983 protein dimerization activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006027 glycosaminoglycan catabolic process
GO:0006029 proteoglycan metabolic process
GO:0007160 cell-matrix adhesion
GO:0008152 metabolic process
GO:0010575 positive regulation vascular endothelial growth factor production
GO:0030194 positive regulation of blood coagulation
GO:0030200 heparan sulfate proteoglycan catabolic process
GO:0030203 glycosaminoglycan metabolic process
GO:0033690 positive regulation of osteoblast proliferation
GO:0042060 wound healing
GO:0044281 small molecule metabolic process
GO:0051797 regulation of hair follicle development
GO:0051798 positive regulation of hair follicle development
GO:0051897 positive regulation of protein kinase B signaling
GO:0060055 angiogenesis involved in wound healing
GO:0061042 vascular wound healing
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0016020 membrane
GO:0043202 lysosomal lumen
GO:0043231 intracellular membrane-bounded organelle
GO:0045121 membrane raft
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Mucopolysaccharidoses pathway
HS-GAG degradation pathway
Myoclonic epilepsy of Lafora pathway
Defective B4GALT7 causes EDS, progeroid type pathway
Defective CHST6 causes MCDC1 pathway
MPS VI - Maroteaux-Lamy syndrome pathway
Defective PAPSS2 causes SEMD-PA pathway
Metabolism of carbohydrates pathway
MPS IIID - Sanfilippo syndrome D pathway
Defective SLC26A2 causes chondrodysplasias pathway
MPS IX - Natowicz syndrome pathway
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
Defective CHST14 causes EDS, musculocontractural type pathway
Heparan sulfate/heparin (HS-GAG) metabolism pathway
MPS IV - Morquio syndrome B pathway
Defective B3GAT3 causes JDSSDHD pathway
Defective CHST3 causes SEDCJD pathway
MPS IV - Morquio syndrome A pathway
Defective EXT2 causes exostoses 2 pathway
Diseases associated with glycosaminoglycan metabolism pathway
MPS II - Hunter syndrome pathway
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
Glycosaminoglycan metabolism pathway
Diseases of glycosylation pathway
MPS VII - Sly syndrome pathway
Defective CHSY1 causes TPBS pathway
Metabolism pathway
MPS I - Hurler syndrome pathway
MPS IIIA - Sanfilippo syndrome A pathway
MPS IIIC - Sanfilippo syndrome C pathway
Disease pathway
Glycogen storage diseases pathway
MPS IIIB - Sanfilippo syndrome B pathway
KEGG
Glycosaminoglycan degradation pathway
INOH
PID BIOCARTA
PID NCI
Syndecan-1-mediated signaling events
Cross-References
SwissProt Q9Y251
TrEMBL
UniProt Splice Variant
Entrez Gene 10855
UniGene Hs.44227 Hs.627092
RefSeq NM_001098540 NM_001166498 NM_001199830 NM_006665
HUGO HGNC:5164
OMIM 604724
CCDS CCDS3602 CCDS54774 CCDS56337
HPRD 05286
IMGT
EMBL AC114781 AF084467 AF144325 AF152376 AF155510 AF165154 AK222986 AM419200 AY948074 BC051321 GQ337901 GQ337902
GenPept AAD41342 AAD45379 AAD45669 AAD54516 AAD54941 AAH51321 AAX47106 ACT98237 ACT98238 BAD96706 CAL91960
RNA Seq Atlas 10855