InnateDB Protein
|
IDBP-481667.4
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
SPAG9
|
Protein Name
|
sperm associated antigen 9
|
Synonyms
|
CT89; HLC-6; HLC4; JIP-4; JIP4; JLP; PHET; PIG6;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000423165
|
InnateDB Gene
|
IDBG-59405 (SPAG9)
|
Protein Structure
|
|
Function |
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg- interaction. {ECO:0000269PubMed:14743216, ECO:0000269PubMed:15693750}.
|
Subcellular Localization |
Cytoplasm. Cytoplasm, perinuclear region. Note=Perinuclear distribution in response to stress signals such as UV radiation.Isoform 5: Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Associated with the plasma membrane of the acrosomal compartment and also localizes in the acrosome matrix.
|
Disease Associations |
|
Tissue Specificity |
Isoform 5 is expressed only in testis on the round spermatids of stage I, II and II. Isoform 5 is absent in spermatogonia and spermatocyte. Isoform 3 is expressed in testis. Isoform 4 is expressed in testis and in acute myeloid leukemia (AML) patients. {ECO:0000269PubMed:14662895, ECO:0000269PubMed:16112646, ECO:0000269PubMed:9480848}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
43
[view]
|
Protein-Protein |
43
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
8 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR017986
WD40-repeat-containing domain
|
PFAM |
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
O60271
|
PhosphoSite |
PhosphoSite-O60271
|
TrEMBL |
Q7Z5Q8
|
UniProt Splice Variant |
|
Entrez Gene |
9043
|
UniGene |
Hs.738131
|
RefSeq |
NP_001238900
|
HUGO |
HGNC:14524
|
OMIM |
605430
|
CCDS |
CCDS58577
|
HPRD |
10398
|
IMGT |
|
EMBL |
AB011088
AC005839
AC005920
AF327452
AF542172
AK023512
AK024068
AK295098
AK302789
AY117689
AY219897
AY219898
AY236487
AY850123
BC007524
BC059946
BC106048
BC146755
BC153878
X91879
|
GenPept |
AAH07524
AAH59946
AAI06049
AAI46756
AAI53879
AAN12270
AAN61565
AAO66462
AAO66463
AAP74807
AAQ11383
AAX47276
BAA25442
BAB14812
BAG51202
BAG58134
BAG63993
CAA62987
|
|
|