Version 5.4
Homo sapiens Gene: SPAG9
Summary
InnateDB Gene IDBG-59405.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPAG9
Gene Name sperm associated antigen 9
Synonyms CT89; HLC-6; HLC4; JIP-4; JIP4; JLP; PHET; PIG6
Species Homo sapiens
Ensembl Gene ENSG00000008294
Encoded Proteins
IDBP-59413
sperm associated antigen 9
IDBP-59417
sperm associated antigen 9
IDBP-481667
sperm associated antigen 9
IDBP-480518
sperm associated antigen 9
IDBP-480854
sperm associated antigen 9
IDBP-483954
sperm associated antigen 9
IDBP-481409
sperm associated antigen 9
IDBP-484330
sperm associated antigen 9
IDBP-811928
sperm associated antigen 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:50962174-51120865
Strand Reverse strand
Band q21.33
Transcripts
ENST00000357122 ENSP00000349636
ENST00000262013 ENSP00000262013
ENST00000509724
ENST00000510283 ENSP00000423165
ENST00000505279 ENSP00000426900
ENST00000506500
ENST00000513746 ENSP00000423346
ENST00000511312
ENST00000513906 ENSP00000430205
ENST00000514613
ENST00000505173
ENST00000514205
ENST00000506483
ENST00000513827
ENST00000515685
ENST00000513547
ENST00000511795 ENSP00000429343
ENST00000510855 ENSP00000426061
ENST00000511987
ENST00000502329
ENST00000576492
ENST00000618113 ENSP00000484908
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 43 [view]
Protein-Protein 43 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008432 JUN kinase binding
GO:0019894 kinesin binding
GO:0048273 mitogen-activated protein kinase p38 binding
Biological Process
GO:0000187 activation of MAPK activity
GO:0007257 activation of JUN kinase activity
GO:0007283 spermatogenesis
GO:0030335 positive regulation of cell migration
GO:0042147 retrograde transport, endosome to Golgi
GO:0042692 muscle cell differentiation
GO:0043410 positive regulation of MAPK cascade
GO:0045666 positive regulation of neuron differentiation
GO:0051146 striated muscle cell differentiation
GO:0051149 positive regulation of muscle cell differentiation
GO:0051260 protein homooligomerization
GO:0090074 negative regulation of protein homodimerization activity
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016021 integral component of membrane
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020859
View Gene Order
ENSBTAG00000012293
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_21402
CDO in myogenesis pathway
REACT_111045
Developmental Biology pathway
REACT_21303
Myogenesis pathway
KEGG
INOH
PID NCI
arf6_traffickingpathway
Arf6 trafficking events
Cross-References
SwissProt O60271
TrEMBL H0Y981
UniProt Splice Variant
Entrez Gene 9043
UniGene Hs.463439 Hs.594826 Hs.710734 Hs.713834 Hs.715865 Hs.738131
RefSeq NM_001130527 NM_001130528 NM_001251971 NM_003971 XM_005257769 XM_005257773 XM_005257774 XM_006722163
HUGO HGNC:14524
OMIM 605430
CCDS CCDS58578 CCDS11577 CCDS45740 CCDS58577
HPRD 10398
IMGT
EMBL AB011088 AC005839 AC005920 AF327452 AK024068 AK295098 AK302789 AY219897 AY219898 AY850123 BC007524 BC059946 BC106048 BC146755 BC153878 X91879
GenPept AAH07524 AAH59946 AAI06049 AAI46756 AAI53879 AAN61565 AAO66462 AAO66463 AAX47276 BAA25442 BAB14812 BAG58134 BAG63993 CAA62987
RNA Seq Atlas 9043

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca