InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PEG10

Summary

InnateDB Protein

IDBP-482080.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PEG10

Protein Name

paternally expressed 10

Synonyms

EDR; HB-1; Mar2; Mart2; MEF3L; RGAG3;

Species

Homo sapiens

Ensembl Protein

ENSP00000418944

InnateDB Gene

IDBG-409089 (PEG10)

Protein Structure

UniProt Annotation

Function

Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Detected predominantly in the cytoplasm of breast and prostate carcinomas, in hepatocellular carcinoma (HCC) and B-cell chronic lymphocytic leukemia (B-CLL) cells and in the Hep-G2 cell line. Colocalized with ALK1.

Disease Associations

Tissue Specificity

Expressed in the cytotrophoblast layer but not in the overlying syncytiotrophoblast of the placenta. Expressed in prostate and breast carcinomas but not in normal breast and prostate epithelial cells. Expressed in the Hep-G2 cell line (at protein level). Expressed in brain, liver, spleen, kidney, thymus, lung, ovary, testis, reactive lymph node, skeletal muscle, adipose tissue and placenta. Expressed in pancreatic and hepatocellular carcinomas (HCC). {ECO:0000269PubMed:11318613, ECO:0000269PubMed:12810624, ECO:0000269PubMed:15611116, ECO:0000269PubMed:16423995, ECO:0000269PubMed:17621626}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	30 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001890	placenta development
GO:0006915	apoptotic process
GO:0030154	cell differentiation
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway