InnateDB Protein
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IDBP-482093.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PDCD10
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Protein Name
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programmed cell death 10
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Synonyms
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CCM3; TFAR15;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000417202
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InnateDB Gene
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IDBG-64018 (PDCD10)
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Protein Structure
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Function |
Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and MST4 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Partially co- localizes with endogenous PXN at the leading edges of migrating cells.
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Disease Associations |
Cerebral cavernous malformations 3 (CCM3) [MIM:603285]: A congenital vascular anomaly of the central nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several centimeters. {ECO:0000269PubMed:15543491}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Ubiquitous. {ECO:0000269PubMed:15543491}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
70
[view]
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Protein-Protein |
65
[view]
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Protein-DNA |
4
[view]
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR009652
Protein of unknown function DUF1241
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PFAM |
PF06840
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BUL8
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PhosphoSite |
PhosphoSite-Q9BUL8
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TrEMBL |
C9JSA3
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UniProt Splice Variant |
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Entrez Gene |
11235
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UniGene |
Hs.478150
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RefSeq |
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HUGO |
HGNC:8761
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OMIM |
609118
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CCDS |
CCDS3202
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HPRD |
10141
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IMGT |
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EMBL |
AC079822
AF022385
AK291130
BC002506
BC016353
CH471052
CR457107
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GenPept |
AAB72225
AAH02506
AAH16353
BAF83819
CAG33388
EAW78574
EAW78575
EAW78576
EAW78577
EAW78578
EAW78579
EAW78580
EAW78581
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