InnateDB Protein
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IDBP-482360.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SH3BP2
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Protein Name
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SH3-domain binding protein 2
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Synonyms
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3BP-2; 3BP2; CRBM; CRPM;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000422605
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InnateDB Gene
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IDBG-7639 (SH3BP2)
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Protein Structure
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Function |
Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.
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Subcellular Localization |
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Disease Associations |
Cherubism (CRBM) [MIM:118400]: An autosomal dominant syndrome characterized by excessive bone degradation of the upper and lower jaws, which often begins around three years of age. It is followed by development of fibrous tissue masses, which causes a characteristic facial swelling. {ECO:0000269PubMed:11381256, ECO:0000269PubMed:12900899, ECO:0000269PubMed:14577811}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Expressed in a variety of tissues including lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269PubMed:9734812}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
48
[view]
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Protein-Protein |
48
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001849
Pleckstrin homology domain
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PFAM |
PF00169
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PRINTS |
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PIRSF |
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SMART |
SM00233
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TIGRFAMs |
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Modification |
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SwissProt |
P78314
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PhosphoSite |
PhosphoSite-P78314
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
6452
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UniGene |
Hs.167679
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RefSeq |
XP_006713975
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HUGO |
HGNC:10825
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OMIM |
602104
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CCDS |
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HPRD |
03657
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IMGT |
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EMBL |
AB000462
AB000463
AF000936
AK299996
AK312286
AL121750
BC022996
CH471131
U56386
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GenPept |
AAB59973
AAB72034
AAH22996
BAA19119
BAA19120
BAG35213
BAG61816
EAW82509
EAW82510
EAW82511
EAW82512
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