Homo sapiens Gene: SH3BP2
Summary
InnateDB Gene IDBG-7639.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SH3BP2
Gene Name SH3-domain binding protein 2
Synonyms 3BP-2; 3BP2; CRBM; CRPM;
Species Homo sapiens
Ensembl Gene ENSG00000087266
Encoded Proteins
SH3-domain binding protein 2
SH3-domain binding protein 2
SH3-domain binding protein 2
SH3-domain binding protein 2
SH3-domain binding protein 2
SH3-domain binding protein 2
SH3-domain binding protein 2
SH3-domain binding protein 2
SH3-domain binding protein 2
SH3-domain binding protein 2
SH3-domain binding protein 2
SH3-domain binding protein 2
SH3-domain binding protein 2
SH3-domain binding protein 2
SH3-domain binding protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:2793023-2841098
Strand Forward strand
Band p16.3
Transcripts
ENST00000356331 ENSP00000348685
ENST00000452765 ENSP00000409746
ENST00000442312 ENSP00000388152
ENST00000435136 ENSP00000403231
ENST00000503219 ENSP00000422796
ENST00000512131
ENST00000510193
ENST00000510074
ENST00000511237
ENST00000504294 ENSP00000423275
ENST00000508385 ENSP00000424917
ENST00000513020 ENSP00000424072
ENST00000511663
ENST00000512014 ENSP00000424105
ENST00000513095 ENSP00000423823
ENST00000502260 ENSP00000425537
ENST00000511185
ENST00000508338
ENST00000503393 ENSP00000422168
ENST00000511747 ENSP00000424846
ENST00000509677
ENST00000515737 ENSP00000422605
ENST00000506932
ENST00000515183
ENST00000505941
ENST00000510204
ENST00000515802
ENST00000504450
ENST00000513069 ENSP00000426818
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 48 [view]
Protein-Protein 48 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
GO:0017124 SH3 domain binding
Biological Process
GO:0007165 signal transduction
GO:0009967 positive regulation of signal transduction
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
TCR pathway
BCR pathway
REACTOME
KEGG
Natural killer cell mediated cytotoxicity pathway
INOH
PID BIOCARTA
PID NCI
TCR signaling in na´ve CD4+ T cells
Cross-References
SwissProt
TrEMBL D6R995 D6RAB4 D6RBL6 D6RC64 D6RER9
UniProt Splice Variant
Entrez Gene 6452
UniGene Hs.167679
RefSeq NM_001122681 NM_001145855 NM_001145856 NM_003023 XM_005247999 XM_006713912
HUGO HGNC:10825
OMIM 602104
CCDS CCDS33944 CCDS54715 CCDS54716
HPRD 03657
IMGT
EMBL AL121750
GenPept
RNA Seq Atlas 6452