Version 5.4
Homo sapiens Gene: SH3BP2
Summary
InnateDB Gene IDBG-7639.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SH3BP2
Gene Name SH3-domain binding protein 2
Synonyms 3BP-2; 3BP2; CRBM; CRPM
Species Homo sapiens
Ensembl Gene ENSG00000087266
Encoded Proteins
IDBP-7641
SH3-domain binding protein 2
IDBP-361081
SH3-domain binding protein 2
IDBP-361084
SH3-domain binding protein 2
IDBP-361089
SH3-domain binding protein 2
IDBP-474804
SH3-domain binding protein 2
IDBP-481127
SH3-domain binding protein 2
IDBP-480381
SH3-domain binding protein 2
IDBP-477487
SH3-domain binding protein 2
IDBP-479625
SH3-domain binding protein 2
IDBP-473387
SH3-domain binding protein 2
IDBP-475990
SH3-domain binding protein 2
IDBP-475111
SH3-domain binding protein 2
IDBP-479968
SH3-domain binding protein 2
IDBP-482360
SH3-domain binding protein 2
IDBP-478909
SH3-domain binding protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:2793023-2841098
Strand Forward strand
Band p16.3
Transcripts
ENST00000356331 ENSP00000348685
ENST00000452765 ENSP00000409746
ENST00000442312 ENSP00000388152
ENST00000435136 ENSP00000403231
ENST00000503219 ENSP00000422796
ENST00000512131
ENST00000510193
ENST00000510074
ENST00000511237
ENST00000504294 ENSP00000423275
ENST00000508385 ENSP00000424917
ENST00000513020 ENSP00000424072
ENST00000511663
ENST00000512014 ENSP00000424105
ENST00000513095 ENSP00000423823
ENST00000502260 ENSP00000425537
ENST00000511185
ENST00000508338
ENST00000503393 ENSP00000422168
ENST00000511747 ENSP00000424846
ENST00000509677
ENST00000515737 ENSP00000422605
ENST00000506932
ENST00000515183
ENST00000505941
ENST00000510204
ENST00000515802
ENST00000504450
ENST00000513069 ENSP00000426818
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 48 [view]
Protein-Protein 48 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
GO:0017124 SH3 domain binding
Biological Process
GO:0007165 signal transduction
GO:0009967 positive regulation of signal transduction
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000054520
View Gene Order
ENSBTAG00000013996
Not yet available
Pathways
NETPATH
NetPath_11
TCR pathway
NetPath_12
BCR pathway
REACTOME
KEGG
hsa04650
Natural killer cell mediated cytotoxicity pathway
INOH
PID NCI
tcr_pathway
TCR signaling in naïve CD4+ T cells
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.167679
RefSeq NM_001122681 NM_001145855 NM_001145856 NM_003023 XM_005247999 XM_006713912
HUGO
OMIM
CCDS CCDS33944 CCDS54715 CCDS54716
HPRD 03657
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca