Version 5.4
Homo sapiens Protein: AWAT2
Summary
InnateDB Protein IDBP-482711.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AWAT2
Protein Name acyl-CoA wax alcohol acyltransferase 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000421172
InnateDB Gene IDBG-74230 (AWAT2)
Protein Structure
UniProt Annotation
Function Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has no activity using decyl alcohol and significantly prefers the C16 and C18 alcohols. May also have 2-acylglycerol O-acyltransferase (MGAT) and acyl- CoA:retinol acyltransferase (ARAT) activities, to catalyze the synthesis of diacylglycerols and retinyl esters; however this activity is unclear in vivo. {ECO:0000269PubMed:15220349, ECO:0000269PubMed:15671038, ECO:0000269PubMed:16106050}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:15220349}; Multi-pass membrane protein {ECO:0000269PubMed:15220349}.
Disease Associations
Tissue Specificity Abundant in tissues rich in sebaceous glands such as the preputial gland and eyelid. Highly expressed in skin, where it is primarily restricted to undifferentiated peripheral sebocytes. Also expressed at lower level in other tissues except pancreas. {ECO:0000269PubMed:15220349, ECO:0000269PubMed:15671038, ECO:0000269PubMed:16106050}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
GO:0047196 long-chain-alcohol O-fatty-acyltransferase activity
GO:0050252 retinol O-fatty-acyltransferase activity
Biological Process
GO:0010025 wax biosynthetic process
GO:0042572 retinol metabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR007130 Diacylglycerol acyltransferase
PFAM PF03982
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6E213
PhosphoSite PhosphoSite-Q6E213
TrEMBL
UniProt Splice Variant
Entrez Gene 158835
UniGene Hs.661507
RefSeq NP_001002254
HUGO HGNC:23251
OMIM 300925
CCDS CCDS35320
HPRD 16799
IMGT
EMBL AY605053 BC063698 BN000156
GenPept AAH63698 AAT68764 CAD89267

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca