Homo sapiens Gene: AWAT2
Summary
InnateDB Gene IDBG-74230.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AWAT2
Gene Name acyl-CoA wax alcohol acyltransferase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000147160
Encoded Proteins
acyl-CoA wax alcohol acyltransferase 2
acyl-CoA wax alcohol acyltransferase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme belonging to the diacylglycerol acyltransferase family. This enzyme produces wax esters by the esterification of long chain (or wax) alcohols with acyl-CoA-derived fatty acids. It functions in lipid metabolism in the skin, mostly in undifferentiated peripheral sebocytes. This enzyme may also have acyl-CoA:retinol acyltransferase activities, where it catalyzes the synthesis of diacylglycerols and retinyl esters. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:70040542-70049938
Strand Reverse strand
Band q13.1
Transcripts
ENST00000276101 ENSP00000421172
ENST00000440401 ENSP00000427523
ENST00000443056
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
GO:0047196 long-chain-alcohol O-fatty-acyltransferase activity
GO:0050252 retinol O-fatty-acyltransferase activity
Biological Process
GO:0008152 metabolic process
GO:0010025 wax biosynthetic process
GO:0042572 retinol metabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
Retinol metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.661507
RefSeq NM_001002254
HUGO
OMIM
CCDS CCDS35320
HPRD 16799
IMGT
EMBL
GenPept
RNA Seq Atlas