Version 5.4
Homo sapiens Protein: KRT20
Summary
InnateDB Protein IDBP-48327.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KRT20
Protein Name keratin 20
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000167588
InnateDB Gene IDBG-48325 (KRT20)
Protein Structure
UniProt Annotation
Function Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:10973561, ECO:0000269PubMed:1696264}.
Disease Associations
Tissue Specificity Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa. Also expressed in the Merkel cells of keratinized oral mucosa; specifically at the tips of some rete ridges of the gingival mucosa, in the basal layer of the palatal mucosa and in the taste buds of lingual mucosa. {ECO:0000269PubMed:10973561, ECO:0000269PubMed:1696264}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0033554 cellular response to stress
GO:0045109 intermediate filament organization
GO:0050708 regulation of protein secretion
Cellular Component
GO:0005737 cytoplasm
GO:0005882 intermediate filament
Protein Structure and Domains
PDB ID
InterPro IPR001664 Intermediate filament protein
IPR002957 Keratin, type I
PFAM PF00038
PRINTS PR01248
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P35900
PhosphoSite PhosphoSite-P35900
TrEMBL
UniProt Splice Variant
Entrez Gene 54474
UniGene Hs.84905
RefSeq NP_061883
HUGO HGNC:20412
OMIM 608218
CCDS CCDS11379
HPRD 12193
IMGT
EMBL AK312744 BC031559 X73501 X73502
GenPept AAH31559 BAG35614 CAA51913 CAA51914

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca