InnateDB Protein
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IDBP-483555.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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WISP1
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Protein Name
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WNT1 inducible signaling pathway protein 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000429185
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InnateDB Gene
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IDBG-36325 (WISP1)
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Protein Structure
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Function |
Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan. {ECO:0000269PubMed:10716946, ECO:0000269PubMed:11782444}.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
Expressed in heart, kidney, lung, pancreas, placenta, ovary, small intestine and spleen. Isoform 2 is expressed predominantly in scirrhous gastric carcinoma and, weakly in placenta. Overexpression is associated with several cancers including breast cancer and colon tumors. Isoform 2 is overexpressed in scirrhous gastric carcinoma.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005520
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insulin-like growth factor binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR006207
Cystine knot, C-terminal
IPR006208
Glycoprotein hormone subunit beta, cystine knot
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PFAM |
PF00007
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PRINTS |
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PIRSF |
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SMART |
SM00041
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TIGRFAMs |
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Modification |
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SwissProt |
O95388
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PhosphoSite |
PhosphoSite-O95388
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
8840
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UniGene |
Hs.492974
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RefSeq |
NP_001191799
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HUGO |
HGNC:12769
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OMIM |
603398
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CCDS |
CCDS56556
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HPRD |
16019
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IMGT |
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EMBL |
AB034725
AF100779
AF192304
AK293031
AK301508
AY196486
AY196487
AY196488
BC074840
BC074841
CH471060
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GenPept |
AAC96321
AAH74840
AAH74841
AAP43924
AAP43925
AAP43926
BAB17849
BAF85720
BAG63017
EAW92162
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