Homo sapiens Gene: WISP1
InnateDB Gene IDBG-36325.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WISP1
Gene Name WNT1 inducible signaling pathway protein 1
Species Homo sapiens
Ensembl Gene ENSG00000104415
Encoded Proteins
WNT1 inducible signaling pathway protein 1
WNT1 inducible signaling pathway protein 1
WNT1 inducible signaling pathway protein 1
WNT1 inducible signaling pathway protein 1
WNT1 inducible signaling pathway protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:133191039-133230344
Strand Forward strand
Band q24.22
ENST00000250160 ENSP00000250160
ENST00000220856 ENSP00000220856
ENST00000377862 ENSP00000367093
ENST00000519433 ENSP00000429185
ENST00000517423 ENSP00000427744
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005520 insulin-like growth factor binding
Biological Process
GO:0001558 regulation of cell growth
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0016055 Wnt signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
UniProt Splice Variant
Entrez Gene
UniGene Hs.492974
RefSeq NM_001204869 NM_001204870 NM_003882 NM_080838
CCDS CCDS56555 CCDS56556 CCDS6371 CCDS6372
HPRD 16019
RNA Seq Atlas