InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: WISP1

Summary

InnateDB Gene

IDBG-36325.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WISP1

Gene Name

WNT1 inducible signaling pathway protein 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000104415

Encoded Proteins

IDBP-36327

WNT1 inducible signaling pathway protein 1

IDBP-36329

WNT1 inducible signaling pathway protein 1

IDBP-36333

WNT1 inducible signaling pathway protein 1

IDBP-483555

WNT1 inducible signaling pathway protein 1

IDBP-476656

WNT1 inducible signaling pathway protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:133191039-133230344

Strand

Forward strand

Band

q24.22

Transcripts

ENST00000250160	ENSP00000250160
ENST00000220856	ENSP00000220856
ENST00000377862	ENSP00000367093
ENST00000519433	ENSP00000429185
ENST00000517423	ENSP00000427744

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005520	insulin-like growth factor binding

Biological Process

GO:0001558	regulation of cell growth
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0016055	Wnt signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000005124

View Gene Order

ENSBTAG00000000707

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.492974

RefSeq

NM_001204869 NM_001204870 NM_003882 NM_080838

HUGO

OMIM

CCDS

CCDS56555 CCDS56556 CCDS6371 CCDS6372

HPRD

16019

IMGT

EMBL

GenPept

RNA Seq Atlas