Version 5.4
Homo sapiens Protein: THOC2
Summary
InnateDB Protein IDBP-483857.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol THOC2
Protein Name THO complex 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000419795
InnateDB Gene IDBG-85061 (THOC2)
Protein Structure
UniProt Annotation
Function Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. Required for NXF1 localization to the nuclear rim. {ECO:0000269PubMed:11979277, ECO:0000269PubMed:15833825, ECO:0000269PubMed:15998806, ECO:0000269PubMed:17190602, ECO:0000269PubMed:18974867, ECO:0000269PubMed:22893130, ECO:0000269PubMed:23222130}.
Subcellular Localization Nucleus {ECO:0000305}. Nucleus speckle {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
Experimentally validated
Total 52 [view]
Protein-Protein 51 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0006397 mRNA processing
GO:0006406 mRNA export from nucleus
GO:0008380 RNA splicing
GO:0016973 poly(A)+ mRNA export from nucleus
GO:0046784 intronless viral mRNA export from host nucleus
Cellular Component
GO:0000346 transcription export complex
GO:0000347 THO complex
GO:0000445 THO complex part of transcription export complex
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID
InterPro IPR021418 THO complex, subunitTHOC2, C-terminal
IPR021726 THO complex, subunitTHOC2, N-terminal
PFAM PF11262
PF11732
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NI27
PhosphoSite PhosphoSite-Q8NI27
TrEMBL
UniProt Splice Variant
Entrez Gene 57187
UniGene Hs.720507
RefSeq
HUGO HGNC:19073
OMIM 300395
CCDS
HPRD 02317
IMGT
EMBL AF441770 AK023659 AL023575 AL030996 BC072400 BX648654 Z82901
GenPept AAH72400 AAM28436 BAB14630 CAE46196 CAI42271 CAI42864 CAO03594

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca