Version 5.4
Homo sapiens Gene: THOC2
Summary
InnateDB Gene IDBG-85061.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol THOC2
Gene Name THO complex 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000125676
Encoded Proteins
IDBP-85063
THO complex 2
IDBP-85065
THO complex 2
IDBP-380250
THO complex 2
IDBP-380271
THO complex 2
IDBP-380277
THO complex 2
IDBP-380282
THO complex 2
IDBP-380284
THO complex 2
IDBP-380285
THO complex 2
IDBP-380287
THO complex 2
IDBP-483857
THO complex 2
IDBP-807608
THO complex 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The TREX multiprotein complex binds specifically to spliced mRNAs to facilitate mRNA export. The protein encoded by this gene is a member of the THO complex, a subset of the TREX complex. The encoded protein interacts with the THOC1 protein.[provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:123600561-123733056
Strand Reverse strand
Band q25
Transcripts
ENST00000355725 ENSP00000347959
ENST00000245838 ENSP00000245838
ENST00000448128 ENSP00000397317
ENST00000441692 ENSP00000415211
ENST00000432353 ENSP00000415947
ENST00000455053 ENSP00000402168
ENST00000416618 ENSP00000415244
ENST00000438358 ENSP00000416639
ENST00000433883 ENSP00000415374
ENST00000419789
ENST00000492203
ENST00000497887
ENST00000491737 ENSP00000419795
ENST00000464992
ENST00000496830
ENST00000464604
ENST00000464982
ENST00000459945
ENST00000464161
ENST00000618150 ENSP00000480478
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
Experimentally validated
Total 52 [view]
Protein-Protein 51 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0006397 mRNA processing
GO:0006406 mRNA export from nucleus
GO:0008380 RNA splicing
GO:0016973 poly(A)+ mRNA export from nucleus
GO:0046784 intronless viral mRNA export from host nucleus
Cellular Component
GO:0000346 transcription export complex
GO:0000347 THO complex
GO:0000445 THO complex part of transcription export complex
GO:0016607 nuclear speck
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000037475
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
hsa03040
Spliceosome pathway
hsa03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.149991 Hs.602862 Hs.611664 Hs.720507
RefSeq NM_001081550 XM_005262450
HUGO
OMIM
CCDS CCDS43988
HPRD 02317
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca