InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CNOT8

Summary

InnateDB Protein

IDBP-483899.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CNOT8

Protein Name

CCR4-NOT transcription complex, subunit 8

Synonyms

CAF1; Caf1b; CALIF; hCAF1; POP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000430493

InnateDB Gene

IDBG-55066 (CNOT8)

Protein Structure

UniProt Annotation

Function

Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. {ECO:0000269PubMed:12771185, ECO:0000269PubMed:19605561, ECO:0000269PubMed:20065043, ECO:0000269PubMed:23236473}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12771185}. Nucleus {ECO:0000269PubMed:12771185}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000175	3'-5'-exoribonuclease activity
GO:0003676	nucleic acid binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003723	RNA binding
GO:0004535	poly(A)-specific ribonuclease activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006417	regulation of translation
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0035195	gene silencing by miRNA
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
GO:0045087	innate immune response (InnateDB)
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic