Version 5.4
Homo sapiens Gene: CNOT8
Summary
InnateDB Gene IDBG-55066.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CNOT8
Gene Name CCR4-NOT transcription complex, subunit 8
Synonyms CAF1; Caf1b; CALIF; hCAF1; POP2
Species Homo sapiens
Ensembl Gene ENSG00000155508
Encoded Proteins
IDBP-55068
CCR4-NOT transcription complex, subunit 8
IDBP-295228
CCR4-NOT transcription complex, subunit 8
IDBP-475694
CCR4-NOT transcription complex, subunit 8
IDBP-483899
CCR4-NOT transcription complex, subunit 8
IDBP-477414
CCR4-NOT transcription complex, subunit 8
IDBP-479540
CCR4-NOT transcription complex, subunit 8
IDBP-481090
CCR4-NOT transcription complex, subunit 8
IDBP-484776
CCR4-NOT transcription complex, subunit 8
IDBP-483709
CCR4-NOT transcription complex, subunit 8
IDBP-478529
CCR4-NOT transcription complex, subunit 8
IDBP-483745
CCR4-NOT transcription complex, subunit 8
IDBP-479630
CCR4-NOT transcription complex, subunit 8
IDBP-479216
CCR4-NOT transcription complex, subunit 8
IDBP-480258
CCR4-NOT transcription complex, subunit 8
IDBP-475016
CCR4-NOT transcription complex, subunit 8
IDBP-483459
CCR4-NOT transcription complex, subunit 8
IDBP-483684
CCR4-NOT transcription complex, subunit 8
IDBP-474091
CCR4-NOT transcription complex, subunit 8
IDBP-482161
CCR4-NOT transcription complex, subunit 8
IDBP-477910
CCR4-NOT transcription complex, subunit 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 23386060
CNOT8 negatively regulates interferon IFN/STAT1 signalling pathway and its depletion results in enhanced response to viral infection.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 5:154857553-154876793
Strand Forward strand
Band q33.2
Transcripts
ENST00000285896 ENSP00000285896
ENST00000403027 ENSP00000384747
ENST00000521174
ENST00000523270
ENST00000518782
ENST00000523698 ENSP00000428565
ENST00000517876 ENSP00000430493
ENST00000520472 ENSP00000430215
ENST00000519211 ENSP00000429108
ENST00000522458 ENSP00000428550
ENST00000519903 ENSP00000428359
ENST00000521450 ENSP00000431034
ENST00000517568 ENSP00000428090
ENST00000524105 ENSP00000429576
ENST00000519430 ENSP00000429310
ENST00000520671 ENSP00000428305
ENST00000521583 ENSP00000429882
ENST00000518028 ENSP00000429810
ENST00000519404 ENSP00000430833
ENST00000519394 ENSP00000428842
ENST00000521729 ENSP00000428600
ENST00000518775 ENSP00000429394
ENST00000522644 ENSP00000428576
ENST00000521402
ENST00000522139
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000175 3'-5'-exoribonuclease activity
GO:0003676 nucleic acid binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003723 RNA binding
GO:0004535 poly(A)-specific ribonuclease activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006417 regulation of translation
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0035195 gene silencing by miRNA
GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
GO:0045087 innate immune response (InnateDB)
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005829 cytosol
GO:0030014 CCR4-NOT complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020515
View Gene Order
ENSBTAG00000012086
Not yet available
Pathways
NETPATH
REACTOME
REACT_20514
Deadenylation of mRNA pathway
REACT_20639
Deadenylation-dependent mRNA decay pathway
REACT_71
Gene Expression pathway
KEGG
hsa03018
RNA degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.26703 Hs.596081 Hs.624491 Hs.740031
RefSeq NM_001301073 NM_001301074 NM_004779 XM_005268527 XM_005268528 XM_006714807
HUGO
OMIM
CCDS CCDS4329 CCDS75361
HPRD 07225
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca