Version 5.4
Homo sapiens Protein: FOXP1
Summary
InnateDB Protein IDBP-483949.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FOXP1
Protein Name forkhead box P1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000419393
InnateDB Gene IDBG-44357 (FOXP1)
Protein Structure
UniProt Annotation
Function Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations Note=A chromosomal aberration involving FOXP1 is found in acute lymphoblastic leukemia. Translocation t(9;3)(p13;p14.1) with PAX5.Mental retardation with language impairment and autistic features (MRLIAF) [MIM:613670]: A developmental disorder characterized by mild to moderate mental retardation, language impairment, and autistic features. Patients show global delay, delayed walking, severely delayed speech development, and behavioral abnormalities, including irritability, hyperactivity, aggression, and stereotypical rigid behaviors. {ECO:0000269PubMed:20950788}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 14 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001766 Transcription factor, fork head
PFAM PF00250
PRINTS PR00053
PIRSF
SMART SM00339
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H334
PhosphoSite PhosphoSite-Q9H334
TrEMBL Q8IXF4
UniProt Splice Variant
Entrez Gene 27086
UniGene Hs.712967
RefSeq NP_001231745
HUGO HGNC:3823
OMIM 605515
CCDS CCDS2914
HPRD 18518
IMGT
EMBL AB052767 AC097632 AC097634 AC103586 AC104442 AC104645 AC138058 AF146696 AF146697 AF146698 AF151049 AF250920 AF275309 AK027264 AK092383 AK122710 AK297649 BC005055 BC054815 BC071893 BC080521 BT006643 CH471055 DQ845346
GenPept AAF36135 AAG47632 AAG47633 AAG47634 AAH05055 AAH54815 AAH71893 AAH80521 AAK69408 AAL56661 AAP35289 ABI33105 BAB55005 BAC03875 BAC53800 BAG53682 BAG60016 EAW65489 EAW65490 EAW65491 EAW65494 EAW65495 EAW65499 EAW65500

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca