Version 5.4
Homo sapiens Protein: DOCK8
Summary
InnateDB Protein IDBP-484109.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DOCK8
Protein Name dedicator of cytokinesis 8
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000419438
InnateDB Gene IDBG-43444 (DOCK8)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 24 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0007264 small GTPase mediated signal transduction
GO:0007596 blood coagulation
GO:0043547 positive regulation of GTPase activity
GO:0061485 memory T cell proliferation
Cellular Component
GO:0005829 cytosol
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR010703 Dedicator of cytokinesis C-terminal
IPR016024 Armadillo-type fold
IPR021816 Dedicator of cytokinesis C/D, N-terminal
PFAM PF06920
PF11878
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NF50
PhosphoSite PhosphoSite-Q8NF50
TrEMBL V9HVZ1
UniProt Splice Variant
Entrez Gene 81704
UniGene Hs.734892
RefSeq NP_001177387
HUGO HGNC:19191
OMIM 611432
CCDS CCDS55284
HPRD 10920
IMGT
EMBL AB191037 AF194407 AK024436 AK074081 AK090429 AL158832 AL161725 AL583913 AL832270 BC019102 BC112894 BC130518 BC143929 EU668358 HM991479
GenPept AAG42221 AAH19102 AAI12895 AAI30519 AAI43930 ACF94511 ADK91777 BAB15726 BAB84907 BAC03410 BAE45254 CAC29497 CAI46160 CAM13234 CAM22536

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca