InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HBEGF

Summary

InnateDB Protein

IDBP-48447.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HBEGF

Protein Name

heparin-binding EGF-like growth factor

Synonyms

DTR; DTS; DTSF; HEGFL;

Species

Homo sapiens

Ensembl Protein

ENSP00000230990

InnateDB Gene

IDBG-48445 (HBEGF)

Protein Structure

UniProt Annotation

Function

Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.

Subcellular Localization

Heparin-binding EGF-like growth factor: Secreted, extracellular space. Note=Mature HB-EGF is released into the extracellular space and probably binds to a receptor.Proheparin-binding EGF-like growth factor: Cell membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	13 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005154	epidermal growth factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0008201	heparin binding

Biological Process

GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007517	muscle organ development
GO:0008016	regulation of heart contraction
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0016477	cell migration
GO:0030307	positive regulation of cell growth
GO:0030335	positive regulation of cell migration
GO:0035313	wound healing, spreading of epidermal cells
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0051545	negative regulation of elastin biosynthetic process
GO:0051549	positive regulation of keratinocyte migration
GO:0051897	positive regulation of protein kinase B signaling
GO:0090303	positive regulation of wound healing