Homo sapiens Protein: LY96
Summary
InnateDB Protein IDBP-484629.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LY96
Protein Name lymphocyte antigen 96
Synonyms ESOP-1; ly-96; MD-2; MD2;
Species Homo sapiens
Ensembl Protein ENSP00000430533
InnateDB Gene IDBG-25842 (LY96)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 19 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001875 lipopolysaccharide receptor activity
GO:0005515 protein binding
GO:0015026 coreceptor activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006954 inflammatory response
GO:0006968 cellular defense response
GO:0007166 cell surface receptor signaling pathway
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032496 response to lipopolysaccharide
GO:0032497 detection of lipopolysaccharide
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0046696 lipopolysaccharide receptor complex
Protein Structure and Domains
PDB ID
InterPro IPR003172 MD-2-related lipid-recognition domain
IPR014756 Immunoglobulin E-set
PFAM PF02221
PRINTS
PIRSF
SMART SM00737
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y6Y9
PhosphoSite PhosphoSite-Q9Y6Y9
TrEMBL
UniProt Splice Variant
Entrez Gene 23643
UniGene Hs.726603
RefSeq NP_001182726
HUGO HGNC:17156
OMIM 605243
CCDS CCDS56540
HPRD 05579
IMGT
EMBL AB018549 AB446498 AC022868 AC087672 AF168121 BC020690
GenPept AAF89635 AAH20690 BAA78717 BAG55275