Version 5.4
Homo sapiens Protein: EIF4EBP3
Summary
InnateDB Protein IDBP-48570.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF4EBP3
Protein Name eukaryotic translation initiation factor 4E binding protein 3
Synonyms 4E-BP3; 4EBP3;
Species Homo sapiens
Ensembl Protein ENSP00000308472
InnateDB Gene IDBG-409438 (EIF4EBP3)
Protein Structure
UniProt Annotation
Function Regulates eIF4E activity by preventing its assembly into the eIF4F complex.
Subcellular Localization
Disease Associations
Tissue Specificity Expression is highest in skeletal muscle, heart, kidney, and pancreas, whereas there is very little expression in brain and thymus. {ECO:0000269PubMed:9593750}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 12 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008190 eukaryotic initiation factor 4E binding
GO:0030371 translation repressor activity
Biological Process
GO:0045947 negative regulation of translational initiation
Cellular Component
GO:0016020 membrane
GO:0016281 eukaryotic translation initiation factor 4F complex
Protein Structure and Domains
PDB ID
InterPro IPR008606 Eukaryotic translation initiation factor 4E binding
PFAM PF05456
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O60516
PhosphoSite PhosphoSite-O60516
TrEMBL
UniProt Splice Variant
Entrez Gene 8637
UniGene
RefSeq NP_003723
HUGO HGNC:3290
OMIM 603483
CCDS CCDS4226
HPRD 09149
IMGT
EMBL AF038869 BC010881 BC069293 BC073751
GenPept AAC39761 AAH10881 AAH69293 AAH73751

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca