Homo sapiens Gene: EIF4EBP3
Summary
InnateDB Gene IDBG-409438.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF4EBP3
Gene Name eukaryotic translation initiation factor 4E binding protein 3
Synonyms 4E-BP3; 4EBP3;
Species Homo sapiens
Ensembl Gene ENSG00000243056
Encoded Proteins
eukaryotic translation initiation factor 4E binding protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the EIF4EBP family, which consists of proteins that bind to eukaryotic translation initiation factor 4E and regulate its assembly into EIF4F, the multi-subunit translation initiation factor that recognizes the mRNA cap structure. Read-through transcription from the neighboring upstream gene (MASK or ANKHD1) generates a transcript (MASK-BP3) that encodes a protein comprised of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:140547666-140549578
Strand Forward strand
Band q31.3
Transcripts
ENST00000310331 ENSP00000308472
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 12 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008190 eukaryotic initiation factor 4E binding
GO:0030371 translation repressor activity
Biological Process
GO:0045947 negative regulation of translational initiation
Cellular Component
GO:0016020 membrane
GO:0016281 eukaryotic translation initiation factor 4F complex
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Cross-References
SwissProt O60516
TrEMBL
UniProt Splice Variant
Entrez Gene 8637
UniGene
RefSeq NM_003732
HUGO HGNC:3290
OMIM 603483
CCDS CCDS4226
HPRD
IMGT
EMBL AF038869 BC010881 BC069293 BC073751
GenPept AAC39761 AAH10881 AAH69293 AAH73751
RNA Seq Atlas 8637