Version 5.4
Homo sapiens Gene: EIF4EBP3
Summary
InnateDB Gene IDBG-409438.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF4EBP3
Gene Name eukaryotic translation initiation factor 4E binding protein 3
Synonyms 4E-BP3; 4EBP3
Species Homo sapiens
Ensembl Gene ENSG00000243056
Encoded Proteins
IDBP-48570
eukaryotic translation initiation factor 4E binding protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the EIF4EBP family, which consists of proteins that bind to eukaryotic translation initiation factor 4E and regulate its assembly into EIF4F, the multi-subunit translation initiation factor that recognizes the mRNA cap structure. Read-through transcription from the neighboring upstream gene (MASK or ANKHD1) generates a transcript (MASK-BP3) that encodes a protein comprised of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:140547666-140549578
Strand Forward strand
Band q31.3
Transcripts
ENST00000310331 ENSP00000308472
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 12 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008190 eukaryotic initiation factor 4E binding
GO:0030371 translation repressor activity
Biological Process
GO:0045947 negative regulation of translational initiation
Cellular Component
GO:0016020 membrane
GO:0016281 eukaryotic translation initiation factor 4F complex
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000090264
View Gene Order
Cross-References
SwissProt O60516
TrEMBL
UniProt Splice Variant
Entrez Gene 8637
UniGene
RefSeq NM_003732
HUGO HGNC:3290
OMIM 603483
CCDS CCDS4226
HPRD
IMGT
EMBL AF038869 BC010881 BC069293 BC073751
GenPept AAC39761 AAH10881 AAH69293 AAH73751
RNA Seq Atlas 8637

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca