InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HAAO

Summary

InnateDB Protein

IDBP-48647.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HAAO

Protein Name

3-hydroxyanthranilate 3,4-dioxygenase

Synonyms

3-HAO; HAO;

Species

Homo sapiens

Ensembl Protein

ENSP00000294973

InnateDB Gene

IDBG-48645 (HAAO)

Protein Structure

UniProt Annotation

Function

Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. {ECO:0000255HAMAP- Rule:MF_03019, ECO:0000269PubMed:7514594}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000334	3-hydroxyanthranilate 3,4-dioxygenase activity
GO:0005506	iron ion binding
GO:0008198	ferrous iron binding
GO:0009055	electron carrier activity
GO:0019825	oxygen binding
GO:0046872	metal ion binding

Biological Process

GO:0006569	tryptophan catabolic process
GO:0010043	response to zinc ion
GO:0019805	quinolinate biosynthetic process
GO:0034354	'de novo' NAD biosynthetic process from tryptophan
GO:0034641	cellular nitrogen compound metabolic process
GO:0043420	anthranilate metabolic process
GO:0044281	small molecule metabolic process
GO:0046686	response to cadmium ion
GO:0046874	quinolinate metabolic process
GO:0055114	oxidation-reduction process
GO:0070050	neuron cellular homeostasis

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0031966	mitochondrial membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR010329 3-hydroxyanthranilic acid dioxygenase
IPR011051 RmlC-like cupin domain
IPR013096 Cupin 2, conserved barrel
IPR016700 3-hydroxyanthranilate 3, 4-dioxygenase, metazoan

PFAM

PF06052
PF07883

PRINTS

PIRSF

PIRSF017681

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P46952