Version 5.4
Homo sapiens Protein: FASTK
Summary
InnateDB Protein IDBP-49062.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FASTK
Protein Name Fas-activated serine/threonine kinase
Synonyms FAST;
Species Homo sapiens
Ensembl Protein ENSP00000297532
InnateDB Gene IDBG-49060 (FASTK)
Protein Structure
UniProt Annotation
Function Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor. {ECO:0000269PubMed:17135269, ECO:0000269PubMed:7544399}.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0033867 Fas-activated serine/threonine kinase activity
Biological Process
GO:0006468 protein phosphorylation
GO:0043484 regulation of RNA splicing
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID
InterPro IPR010622 FAST kinase leucine-rich
IPR013579 FAST kinase-like protein, subdomain 2
IPR013584 RAP domain
PFAM PF06743
PF08368
PF08373
PRINTS
PIRSF
SMART SM00952
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q14296
PhosphoSite PhosphoSite-Q14296
TrEMBL
UniProt Splice Variant
Entrez Gene 10922
UniGene Hs.647094
RefSeq NP_006703
HUGO HGNC:24676
OMIM 606965
CCDS CCDS5918
HPRD 07368
IMGT
EMBL AB209783 AC010973 AK292232 BC011770 BC039026 CH471173 X86779
GenPept AAH11770 AAH39026 BAD93020 BAF84921 CAA60448 EAW54039 EAW54043

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca