Version 5.4
Homo sapiens Gene: FASTK
Summary
InnateDB Gene IDBG-49060.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FASTK
Gene Name Fas-activated serine/threonine kinase
Synonyms FAST
Species Homo sapiens
Ensembl Gene ENSG00000164896
Encoded Proteins
IDBP-49062
Fas-activated serine/threonine kinase
IDBP-49064
Fas-activated serine/threonine kinase
IDBP-476951
Fas-activated serine/threonine kinase
IDBP-591228
Fas-activated serine/threonine kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:151076593-151080866
Strand Reverse strand
Band q36.1
Transcripts
ENST00000297532 ENSP00000297532
ENST00000353841 ENSP00000324817
ENST00000489884
ENST00000465272
ENST00000467237
ENST00000482571 ENSP00000418516
ENST00000460980
ENST00000469237
ENST00000482806
ENST00000483953
ENST00000466855
ENST00000459800
ENST00000478477
ENST00000461979
ENST00000478883
ENST00000496663
ENST00000540185 ENSP00000444498
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0033867 Fas-activated serine/threonine kinase activity
Biological Process
GO:0006468 protein phosphorylation
GO:0043484 regulation of RNA splicing
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028959
View Gene Order
ENSBTAG00000011228
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.647094
RefSeq NM_001258461 NM_006712 NM_033015 XM_005249932 XM_005249933
HUGO
OMIM
CCDS CCDS59088 CCDS5918 CCDS5919
HPRD 07368
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca