InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD14

Summary

InnateDB Protein

IDBP-49159.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD14

Protein Name

CD14 molecule

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000304236

InnateDB Gene

IDBG-49157 (CD14)

Protein Structure

UniProt Annotation

Function

In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the MD-2/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules. {ECO:0000269PubMed:23264655}.

Subcellular Localization

Cell membrane; Lipid-anchor, GPI-anchor.

Disease Associations

Tissue Specificity

Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	33 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001530	lipopolysaccharide binding
GO:0001847	opsonin receptor activity
GO:0005515	protein binding
GO:0016019	peptidoglycan receptor activity
GO:0070891	lipoteichoic acid binding

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0002237	response to molecule of bacterial origin
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0006909	phagocytosis
GO:0006915	apoptotic process
GO:0006954	inflammatory response
GO:0007166	cell surface receptor signaling pathway
GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0009408	response to heat
GO:0032026	response to magnesium ion
GO:0032496	response to lipopolysaccharide
GO:0032760	positive regulation of tumor necrosis factor production
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034612	response to tumor necrosis factor
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0045471	response to ethanol
GO:0045807	positive regulation of endocytosis
GO:0050715	positive regulation of cytokine secretion
GO:0051602	response to electrical stimulus
GO:0071222	cellular response to lipopolysaccharide
GO:0071223	cellular response to lipoteichoic acid

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0010008	endosome membrane
GO:0031225	anchored component of membrane
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome