InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CD14

Summary

InnateDB Gene

IDBG-49157.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD14

Gene Name

CD14 molecule

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000170458

Encoded Proteins

IDBP-49159

CD14 molecule

IDBP-295549

CD14 molecule

IDBP-476993

CD14 molecule

IDBP-485042

CD14 molecule

IDBP-476906

CD14 molecule

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 19776284

CD14 co-receptor participates with toll-like receptors (TLRs) in the response of microglial cells to fibrillar forms of beta-amyloid, contributing to microglial activation.

PMID 19840871

CD14 recognizes necrotic cells in addition to LPS, PG, apoptotic cells, and lipids, suggesting that it might be a universal adaptor for damage-associated molecular pattern (DAMP) and pathogen-associated molecular patterns (PAMP).

PMID 10652232

CD14 is a molecule that binds to lipopolysaccharide (LPS) and facilitates its signalling by helping TLR4-LY96 to sense and signal the presence of LPS.

PMID 21078886

CD14 contributes to nucleic acid uptake in macrophages and acts as a co-receptor for endosomal TLR7/TLR9 activation.

PMID 23548899

CD14 acts as an adaptor molecule for the immune recognition of salmonella curli fibers.

InnateDB Annotation from Orthologs

Summary

PMID 21078886

[Mus musculus] Cd14 contributes to nucleic acid uptake in macrophages and acts as a co-receptor for endosomal Tlr7/Tlr9 activation.

Entrez Gene

Summary

The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:140631728-140633701

Strand

Reverse strand

Band

q31.3

Transcripts

ENST00000302014	ENSP00000304236
ENST00000401743	ENSP00000385519
ENST00000498971	ENSP00000426543
ENST00000519715	ENSP00000430884
ENST00000512545	ENSP00000425447

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	33 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001530	lipopolysaccharide binding
GO:0001847	opsonin receptor activity
GO:0005515	protein binding
GO:0016019	peptidoglycan receptor activity
GO:0070891	lipoteichoic acid binding

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0002237	response to molecule of bacterial origin
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0006909	phagocytosis
GO:0006915	apoptotic process
GO:0006954	inflammatory response
GO:0007166	cell surface receptor signaling pathway
GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0009408	response to heat
GO:0032026	response to magnesium ion
GO:0032496	response to lipopolysaccharide
GO:0032760	positive regulation of tumor necrosis factor production
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034612	response to tumor necrosis factor
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0045471	response to ethanol
GO:0045807	positive regulation of endocytosis
GO:0050715	positive regulation of cytokine secretion
GO:0051602	response to electrical stimulus
GO:0071222	cellular response to lipopolysaccharide
GO:0071223	cellular response to lipoteichoic acid

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0010008	endosome membrane
GO:0031225	anchored component of membrane
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome