Homo sapiens Gene: CD14
Summary
InnateDB Gene IDBG-49157.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD14
Gene Name CD14 molecule
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000170458
Encoded Proteins
CD14 molecule
CD14 molecule
CD14 molecule
CD14 molecule
CD14 molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
CD14 co-receptor participates with toll-like receptors (TLRs) in the response of microglial cells to fibrillar forms of beta-amyloid, contributing to microglial activation.
CD14 recognizes necrotic cells in addition to LPS, PG, apoptotic cells, and lipids, suggesting that it might be a universal adaptor for damage-associated molecular pattern (DAMP) and pathogen-associated molecular patterns (PAMP).
CD14 is a molecule that binds to lipopolysaccharide (LPS) and facilitates its signalling by helping TLR4-LY96 to sense and signal the presence of LPS.
CD14 contributes to nucleic acid uptake in macrophages and acts as a co-receptor for endosomal TLR7/TLR9 activation.
CD14 acts as an adaptor molecule for the immune recognition of salmonella curli fibers.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Cd14 contributes to nucleic acid uptake in macrophages and acts as a co-receptor for endosomal Tlr7/Tlr9 activation.
Entrez Gene
Summary The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:140631728-140633701
Strand Reverse strand
Band q31.3
Transcripts
ENST00000302014 ENSP00000304236
ENST00000401743 ENSP00000385519
ENST00000498971 ENSP00000426543
ENST00000519715 ENSP00000430884
ENST00000512545 ENSP00000425447
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein-Protein 33 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001530 lipopolysaccharide binding
GO:0001847 opsonin receptor activity
GO:0005515 protein binding
GO:0016019 peptidoglycan receptor activity
GO:0070891 lipoteichoic acid binding
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0002237 response to molecule of bacterial origin
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006909 phagocytosis
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0007166 cell surface receptor signaling pathway
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0009408 response to heat
GO:0032026 response to magnesium ion
GO:0032496 response to lipopolysaccharide
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034612 response to tumor necrosis factor
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0045471 response to ethanol
GO:0045807 positive regulation of endocytosis
GO:0050715 positive regulation of cytokine secretion
GO:0051602 response to electrical stimulus
GO:0071222 cellular response to lipopolysaccharide
GO:0071223 cellular response to lipoteichoic acid
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0031225 anchored component of membrane
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Transfer of LPS from LBP carrier to CD14 pathway
TRIF-mediated programmed cell death pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Innate Immune System pathway
IKK complex recruitment mediated by RIP1 pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
TRAF6 mediated induction of TAK1 complex pathway
Immune System pathway
MyD88-independent cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Activated TLR4 signalling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
KEGG
MAPK signaling pathway pathway
Phagosome pathway
Toll-like receptor signaling pathway pathway
Hematopoietic cell lineage pathway
Regulation of actin cytoskeleton pathway
Pathogenic Escherichia coli infection pathway
Amoebiasis pathway
INOH
Toll-like receptor signaling pathway pathway
PID BIOCARTA
Toll-like receptor pathway [Biocarta view]
Inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages [Biocarta view]
PID NCI
Beta1 integrin cell surface interactions
Alpha4 beta1 integrin signaling events
Endogenous TLR signaling
Cross-References
SwissProt P08571
TrEMBL D6RD81 D6RFL4 E7EVL5
UniProt Splice Variant
Entrez Gene 929
UniGene Hs.163867
RefSeq NM_001040021 NM_001174104 NM_001174105 NM_000591
HUGO HGNC:1628
OMIM 158120
CCDS CCDS4232
HPRD 01151
IMGT
EMBL AB446505 AC116353 AF097942 AY044269 BC010507 BT007331 CH471062 M86511 X06882 X13334
GenPept AAA51930 AAC83816 AAH10507 AAL02401 AAP35995 BAG55282 CAA29999 CAA31711 EAW62037
RNA Seq Atlas 929