InnateDB Protein
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IDBP-49563.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GDI2
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Protein Name
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GDP dissociation inhibitor 2
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Synonyms
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HEL-S-46e; RABGDIB;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000369538
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InnateDB Gene
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IDBG-49561 (GDI2)
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Protein Structure
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Function |
Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. {ECO:0000269PubMed:7543319}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
34
[view]
|
Protein-Protein |
32
[view]
|
Protein-DNA |
1
[view]
|
Protein-RNA |
1
[view]
|
DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
|
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Predicted by orthology |
Total |
1 [view]
|
|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000806
Rab GDI protein
IPR018203
GDP dissociation inhibitor
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PFAM |
PF00996
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PRINTS |
PR00892
PR00891
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P50395
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PhosphoSite |
PhosphoSite-P50395
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TrEMBL |
V9GYF8
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UniProt Splice Variant |
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Entrez Gene |
2665
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UniGene |
Hs.660588
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RefSeq |
NP_001485
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HUGO |
HGNC:4227
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OMIM |
600767
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CCDS |
CCDS7071
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HPRD |
02863
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IMGT |
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EMBL |
AB451295
AB451429
AF144713
AK122841
AK297554
AK312485
AL596094
BC005145
BT006868
CH471072
CR457073
D13988
EU794614
Y13286
Y13287
Y13288
Y13289
Y13290
Y13291
Y13292
Y13293
Y13294
Y13295
Y13296
Y13297
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GenPept |
AAD34588
AAH05145
AAP35514
ACJ13668
BAA03095
BAG35388
BAG53755
BAG59947
BAG70109
BAG70243
CAA73734
CAA73735
CAG33354
CAI13363
EAW86431
EAW86432
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